Page 51 - 《精细化工》2023年第4期

す 4 ᱌ ᑍუᏤ喑ぶ: ᓛ䕇䖀ࣺᏁக͚㇫㏳ࡃ႓৮व᜽࢞䮖ጒ㞧ⵁ⾣䔈ᆂ g737g

⢴ᅞज䓫ݝ 100%喑ౕ㏬䓽䒙 100 h יࡃݯ≨ᕔ᱗㻮 ݣࣺᏁ⍖Ꮣ 40 ĎȠ⊀Ꮣ 1 mol/L ⮱ MBY ⩟䚴⏣⋟
ᬻ̸᭫䭺ȡ ≮䕌 0.02 mL/minȠ⅏⅁ࢸ߈হ≮䕌ܳݘͧ 0.1 MPa
হ 0.06 mL/min ᬣ喑䔋㐚ౕ㏬ 65 h喑MBY ⮱䒙ࡃ⢴
হ 2-⩟ധ-3-̮☜-2-䚴⮱ᩣ⢴໸㏵Ԋᠮౕ 99%হ
95.8%喑㶕ᬻיࡃݯᅯڤᰶхᐯיࡃᕔ㘪হ⽠Ⴧᕔȡ
Ⱕ䒰λ䜉ᐼࣺᏁ喑ϔ৮ღᭀܳ⻨喑ᩣ⢴ᬻ᭫᣽倅喑
Ⴖڕᕔᓄݝᩦ䔈ȡ

ఫ 23 ⊯㺳 UiO-66-NH 2 /Pd ᅯ⮱ᓛ䕇䖀ࣺᏁக͚ 4-ⶊധ
㠜䚇⮱䔅ࣺ࣌Ꮑ [86]
Fig. 23 Catalytic reduction of 4-nitrophenol in microchannel
reactor coated with UiO-66-NH 2 /Pd [86]

㟼ͧ⻾䄫䷅㏱ [88] ᄳ䧊ࡃ⮱ Raney Ni יࡃݯ඘ ఫ 25 ⊯㺳 Pd 50 Zn 50 /Ti 0.95 Ce 0.05 O 2 ᅯ⮱ᓛ䕇䖀ࣺᏁக͚
ٲݝڲᒱ 4.6 mm喑䪬Ꮣ 15 cm ⮱倅᩵⋟Ⱕ㞟䅞ᴞ͚ 2-⩟ധ-3-̮◁-2-䚴⮱䔶᠖ᕔיࡃߍ⅏ࣺᏁ [89-90]
Fig. 25 Selective catalytic hydrogenation of 2-methyl-3-
ݣᓄ඘ٲᎷᓛࣺᏁக喑Ꭳ䙺㒛 0.2 MPa ⮱㗹ࢸ䬭ȡ
butyne-2-ol in microchannel reactor coated with
䄒ࣺᏁக⩕λٸਾᰬᅩ喍Crizotinib喎व᜽͚⮱ࡰٸ Pd 50 Zn 50 /Ti 0.95 Ce 0.05 O 2 [89-90]
㏔ⶊധ͚䬡Ҁ⮱䔅࣌喍ఫ 24喎ȡߍ⅏ࣺᏁ䓴⼸͚喑
ओ̭ㆨ䔶᠖ᕔיࡃߍ⅏ࣺᏁ᭜ࣹⷠⷠ䩛̻㓝ധ
⩕䉕䛼≮䛼䃎ᣔݣ⩞䧏⨣≮ܧ⮱⅏⅁喑⅏⅁ࢸ߈
0.72~0.83 MPa喑ᴞඋ∢∢ڒⶊധ͚䬡Ҁ⮱ι⅜⩟☤ ڞ䒚Ҁ㈨͚㓝ധ⮱䔶᠖ᕔߍ⅏ȡBAI ぶ [91] ᄳ 12%喍䉕
⏣⋟ȡᒀᣔݣࣺᏁ⍖Ꮣ 25 ĎȠ։⪆ᬣ䬡ͧ 6 s ᬣ喑 䛼ܳ᪝喎Pt/SiO 2 ⊯㺳λڲᒱ 1.27 mmȠ䪬Ꮣ 5 m ⮱
⅕ധ͚䬡Ҁ⮱ᩣ⢴倅䓫 98%ȡࣺᏁ᩵⢴Ƞ䔶᠖ᕔহ 316 L ̺䨵䧏℈㏳ノڲ෮ᒏ᜽יࡃݯᅯ喑ݣิܧ⩕λ
Ⴖڕᕔ౴᭫㦄᣽倅喑᭫⹧ܧₑㆨᓛ䕇䖀ࣺᏁகౕጒ 㖶ᵯ䛈䔶᠖ᕔߍ⅏व᜽㖶ᵯ䚴⮱ᓛ䕇䖀ࣺᏁகȡౕ
͇⩌ϔ̷⮱Ꮑ⩕⒉߈ȡѳౕ჋侹͚䮼ⱭࣺᏁ⊀Ꮣহ ࣺᏁ⍖Ꮣ 150 ĎȠH 2 ≮䕌 3 mL/minȠ⊀Ꮣ 0.8 mol/L
יࡃݯ⩕䛼⮱෋ߍ喑יࡃݯчൢඋ㗹ࢸ䬭喑䄒඘ٲ ⮱㖶ᵯ䛈ᐯ͆䚴⏣⋟≮䕌 0.2 mL/minȠࣺᏁࢸ߈
ᎷࣺᏁகႅౕࢸ䭺䬛䷅喑ज䕇䓴ౕࣺᏁノ͚඘ٲ䶱 1.5 MPa ⮱ጒ㞧 ᲎У̸喑㖶 ᵯ 䛈⮱䒙ࡃ ⢴倅 䓫
ܳ㼐⮱יࡃݯ喑⌨ߍᕿ⍖கᣔݣࣺᏁ⍖ᏓᲒ㼐۠ȡ 98.8%喑㖶ᵯ䚴⮱䔶᠖ᕔͧ 90.0%喑ࣺᏁ 110 h ⮱䒙
ࡃ᪝䓫ݝ 3000喑౴хλ䜉ᐼহధჇᎷࣺᏁக͚⮱㐀
᳉ȡיࡃݯ๞≨ऻ㏼ౕ㏬䔅࣌হ⏣ݯ۟≄ᖏฺຯ݊喑
㶕ᬻיࡃݯ⊯ᅯڤᰶ㞜ສ⮱⽠ჇᕔВࣺࣷᏁக⒉ౕ
⮱㻱὎ࡃᏁ⩕ݺᮜȡ

6 㐀᲌䄚̻ᆂ᱈
ఫ 24 Raney Ni יࡃݯ඘ٲᎷࣺᏁக͚ٸਾᰬᅩⶊധ͚
䬡Ҁ⮱יࡃߍ⅏ࣺᏁ [88] ᱙᪴ᕨ㐀γ᫝ಸᓛ䕇䖀ࣺᏁக⮱䃫䃎ȠᲱᐧহ
Fig. 24 Catalytic hydrogenation of nitro intermediate of Ⱕڠϔ৮ౕᓛ䕇䖀ࣺᏁக͚व᜽ጒ㞧⮱ⵁ⾣䔈ᆂ喑
Crizotinib in Raney Ni packed bed reactor [88]
⋢Ⰳγᩫ☚ޔ◵ȠࣺᏁ➖ᝃϔ➖̺⽠ჇȠ➖᫆䙺℁
CŋC 䔶᠖ᕔ䘕ܳߍ⅏⩌᜽ C==C ᭜יࡃߍ⅏䶳 ͒ᵩȠ倅⍖倅ࢸぶ࢞䮖ࣺᏁጒ㞧喑̻పუⴠࡃࡃጒ
ഌᠾᝅᕔ䄫䷅ȡڣ͚喑◁䚴䔶᠖ᕔיࡃߍ⅏⩌᜽☜ 㵹͇呀ߞᣕᎬᏁ⩕⮱ឭᱜহϔ৮Ⱋᒂ⮱す̭᲎Ą᫝
䚴᭜䃥็㇫㏳ࡃ႓৮व᜽ጒ㞧͚⮱ڠ䩛ₒ俑ȡⰛݺ喑 ಸᓛ䕇䖀ࣺᏁக㷲ิࣷ䔋㐚≮ጒ㞧ឭᱜą⮱㠰⪡Ⱕ
◁䚴䔶᠖ᕔיࡃߍ⅏⩌᜽☜䚴็ౕ≳ᔮᎷࣺᏁக͚ ๾व [92] ȡϻ͚ࣾ⣝喟喍1喎ᓛࣺᏁக⮱ᱽ䉕̻ࣺᏁ➖
䔈㵹喑ႅౕיࡃݯ⸕ᢌ喑יࡃݯఋᩣఝ䯫⮱䬛䷅喠 ౕࣺᏁகڲ㶕䲏⮱౴࠭ܳጰВࣷ㔽㙽㮭ᕔჳܴⰥ
㔹́喑⩞λ≳ᔮᎷࣺᏁக͚ႅౕ䔁⌤⣝䆎喑Ҭᓄࣺ ڠ喑ϻ㔹ᒞ৺ࣺᏁ㘪॓䶧ݖ䔈㵹喠喍2喎౴Ⱕᝃ⅁-
Ꮑ⮱䒙ࡃ⢴হ䔶᠖ᕔ౴ᰶ᝭䭺ѻȡͧ㼐۠䔆ψ䬛䷅喑 ⋟͑ⰥࣺᏁजВౕ㏼ڥ⮱℈㏳ノ㏬వࣺᏁகڲ䔈
OKHLOPKOVA ぶ [89-90] ౕⰡᒱ 530 ȝm ⮱℈㏳ノڲ 㵹喑䕇䓴ጒ㞧࣯᪝⮱хࡃजВ䓫ݝ⤳ᘠ⮱㐀᳉喑
෮⊯㺳 Pd 50 Zn 50 /Ti 0.95 Ce 0.05 O 2 יࡃݯᅯ喑ݣิγᓛ䕇 ڣ͚։⪆ᬣ䬡᭜ͨ㺮఍㉍喠喍3喎ᄦλٶיࡃࣺᏁ喑
䖀ࣺᏁக⩕λ 2-⩟ധ-3-̮◁-2-䚴喍MBY喎⮱䔶᠖ ᓛࣺᏁக⮱Ჱಸ䃫䃎Ꮑ␎䋠ᅪज㘪๔⮱ऄٶ䲏⼜喠
ᕔ䘕ܳߍ⅏व᜽ 2-⩟ധ-3-̮☜-2-䚴喍ఫ 25喎ȡᒀᣔ 喍4喎ᄦλ⅁-⋟-⋟̶ⰥࣺᏁ喑ᓛࣺᏁக⮱䃫䃎仃ٵ