Page 104 - 《精细化工》2019年第11期

第 36 卷第 11 期 精 细 化 工 Vol.36, No.11
2019 年 11 月 FINE CHEMICALS Nov. 2019

食品与饲料用化学品
二甲酸钾微胶囊的构建与缓释抑菌性

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孟祥俭 ，郭小炜 ，李玉妍 ，王秀丽 ，解庆林 ，陈南春
（1. 桂林理工大学 材料科学与工程学院，广西工业废渣建材资源利用工程技术研究中心，广西 桂林
541000；2. 桂林理工大学 化学与生物工程学院，广西 桂林 541000；3. 桂林理工大学 环境科学与工程
学院，广西 桂林 541000）
摘要：以自制沸石分子筛为载体，通过水热法将二甲酸钾负载形成芯材，海藻酸钠、壳聚糖为壳材，以复凝聚
法制备出缓释微胶囊。通过 FTIR、XPS 对微胶囊进行了结构表征，通过缓释及抑菌率测试对其性能进行表征。
结果表明：沸石分子筛与二甲酸钾之间可形成复配效应，构成微胶囊的芯材；壳聚糖和海藻酸钠发生静电作用，
形成聚电解质膜，构成微胶囊的壳材；制备的微胶囊在 pH=2.0 的模拟胃环境中稳定，在 pH=7.2 的模拟肠道环
境中二甲酸钾得到了释放，并在 3 h 内可释放完全；微胶囊包封率为 68.33%，二甲酸钾的释放量为 137.50 mg/g。
微胶囊对大肠杆菌的生长具有一定的抑制作用，并随着微胶囊浓度的增大对大肠杆菌的抑制率呈现增长的趋势，
最高抑菌率可以达到 85%。
关键词：沸石分子筛；二甲酸钾；海藻酸钠；壳聚糖；微胶囊；缓释；饲料用化学品
中图分类号：TB332；TQ460.1 文献标识码：A 文章编号：1003-5214 (2019) 11-2252-07

Construction and Sustained Release Bacteriostasis of

Potassium Diformate Microcapsules

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MENG Xiang-jian , GUO Xiao-wei , LI Yu-yan , WANG Xiu-li ,
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XIE Qing-lin , CHEN Nan-chun
（1. Guangxi Engineering Research Center for Solid Waste Resources Development and Application, School of Materials
Science and Engineering, Guilin University of Technology, Guilin 541000, Guangxi, China; 2. School of Chemical and
Biological Engineering, Guilin University of Technology, Guilin 541000, Guangxi, China; 3. School of Environmental Science
and Engineering, Guilin University of Technology, Guilin 541000, Guangxi, China）
Abstract: Potassium diformate (KDF) was loaded on self-made zeolite by hydrothermal method. It was
used as core material, sodium alginate (SA) and chitosan (CS) was used as shell material to prepare
sustained-release microcapsules by a complex coacervation method. The structure of the sample was
characterized by FTIR and XPS. The performance was characterized by sustained release and inhibition rate
experiment. The results showed that compound effect was formed between zeolite and KDF to form the
core material of the microcapsules, CS and SA formed polyelectrolyte membranes through electrostatic
interaction as the shell materials of the microcapsules. The microcapsules were stable in the pH=2.0
simulated environment of stomach. In the pH=7.2 environment of intestinal, KDF of microcapsules was
completely released within 3 h. The entrapment efficiency was 68.33%, the release amount of KDF in
microcapsules were 137.50 mg/g. The prepared microcapsules had an inhibitory effect on the growth of E.
coli. The inhibition rate against E. coli increased with the increase of the concentration of microcapsules
and the highest inhibition rate reached 85%.
Key words: zeolite; potassium diformate; sodium alginate; chitosan; microcapsules; sustained release;
feedstuff chemicals

收稿日期：2019-04-28; 定用日期：2019-06-18; DOI: 10.13550/j.jxhg.20190375
基金项目：国家自然科学基金（41662005；51564008）；广西自然科学基金（2015GXNSFAA139094；2016GXNSFAA380014）
作者简介：孟祥俭（1988—），男，硕士生，E-mail：1249844819@qq.com。联系人：陈南春（1962—），男，教授，E-mail：cnc@glut.edu.cn。