Page 137 - 201904
P. 137

第 4 期                       丛景香,等:  异甘草素键合硅胶固定相的合成及应用                                    ·663·


                                                               [3]   Ding  X  L,Yang  J,  Dong  Y  M.Advancements  in  the  preparation  of
                                                                   high-performance liquid chromatographic organic polymer monoliths
                                                                   for the separation of small-molecule drugs[J]. J Pharm Anal, 2018,
                                                                   8(2): 75-85.
                                                               [4]   Jiao Chunxia (焦春霞), Wang Gang (王刚). Research progress on the
                                                                   bonded  silica  gel  stationary  phase  of  natural  product  components
                                                                   with  high  performance  liquid  chromatography[J].  Journal  of  Food
                                                                   Safety  and  Quality  (食品安全质量检测学报),  2018,  9  (10):  2304-
                                                                   2310.
                                                               [5]   Li Laisheng (李来生), Chen Hong (陈红), Ma Haiping (马海萍), et
                                                                   al.  Preparation,  characterization  and  performance  evaluation  of
                                                                   magnolol-bonded  silica  gel  liquid  chromatography  stationary  phase

                                                                   [J]. Chem J Chin Univ (高等学校化学学报), 2012, 33(4): 707-713.
                      图 7    中药提取物的分离色谱图                       [6]   Li Laisheng (李来生), Chen Xiongquan (陈雄泉), Yang Hanrong (杨
              Fig. 7    Chromatograms of the Chinese medicine extracts   汉荣),  et al.  Preparation  and  characterization  of  baicalin-bonded
                                                                   silica  gel  stationary  phase[J].  Anal  Chem  (分析化学),  2007,  7(9):
                                                                   1279-1284.
            长只有 30 mm 的 2 号色谱柱对复杂多组分也表现出
                                                               [7]   Fang Yishan (方奕珊), Li Laisheng (李来生), Chen Hong (陈红), et
            较好的分离能力。由于反应路径不同,使得合成的                                 al. Study on the quercetin-bonded silica gel phase for the separations
            ISLSP-Ⅱ较 ISLSP-Ⅰ固定相更具平面线型或两固定                          of polar compounds by high-performance liquid chromatography[J].
                                                                   Chin J Appl Chem (应用化学), 2013, 30(1): 79-87.
            相的剩余羟基数目不同,可能是 2 号柱分离多组分                           [8]   Xu  Lili  (许丽丽),  Zhong  Minghua  (衷明华),  Chen  Xiaojing  (陈小
            效果更好的原因。                                               静).  Preparation  and  chromatographic  performance  of  a  eugenol-
                                                                   bonded  silica  gel  stationary  phase  for  high  performance  liquid
            3   结论                                                 chromatography[J]. Chin J Chromatogr (色谱), 2015, 33(5): 461-467.
                                                               [9]   Gu Xiaojuan (谷晓娟), Han Yaqiong (韩亚琼), Li Xinyi (李心怡), et
                                                                   al. Preparation, characterization and application of ginsenoside Rg1
                 通过液相连续反应法和中间体法成功将异甘草                              bonded silica gel stationary phase[J]. Res Dev Nat Prod (天然产物研
            素配体键合于硅胶基质制备了 ISLSP-Ⅰ和 ISLSP-                          究与开发), 2014, 26 (6): 824-829.
                                                               [10]  Zhang Y, Luo H, Carr P W.Silica-based,hyper-crosslinked acid stable
            Ⅱ固定相。两固定相在色谱性能上存在一定差异,
                                                                   stationary phases for high performance liquid chromatography[J]. J
            ISLSP-Ⅱ固定相具有反相分离机制,而 ISLSP-Ⅰ固                          Chromatogr A, 2012, 1228: 110-124.
            定相则不明显,可能存在更复杂的分离机制。异甘                             [11]  Wu T Y, Khor T O, Saw C L, et al. Anti-inflammatory/anti-oxidative
                                                                   stress activities and differential regulation of Nrf2-mediated genes by
            草素的平面共轭结构使得合成固定相具有更为良好                                 non-polar  fractions  of  tea  Chrysanthemum  zawadskii  and  licorice
            的稳定性,6 个月使用期间,两柱对待分离组分的                                Glycyrrhiza uralensis[J]. AAPS J, 2011, 13(1): 1-13.
                                                               [12]  Chen  H-Y,  Huang  T-C,  Shieh  T-M,et al.  Isoliquiritigenin  induces
            色谱性能变化很小 ( 保 留时间相对偏差不超过
                                                                   autophagy and inhibits ovarian cancer cell growth[J]. Int J Mol Sci,
            0.9%)。两种方法合成的固定相对于多组分的分离具                              2017, 18(10): 2025.
            有较好的能力。                                            [13]  Cronin  H,  Draelos  Z  D.  Top  10  botanical  ingredients  in  2010
                                                                   anti-aging creams[J]. J Cosmet Dermatol, 2010, 9(3): 218-225.
                                                               [14]  Chen Tianbao, Deng Shaoxiong, Lin Rong. The inhibitory effect of
            参考文献:
                                                                   Isoliquiritigenin on the proliferation of human arterial smooth muscle
            [1]   Ou Junjie (欧俊杰),  Zou  Hanfa  (邹汉法).  Liquid  chromatographic   cell[J]. BMC Pharmacol Toxicol, 2017, 18: 57.
                 separation  material:  the  preparation  and  application[M].  Beijing:   [15]  Xu  Lili  (许丽丽),  Ren  Nailin  (任乃林), Lin Zeling  (林泽玲).
                 Chemical Industry Press (化学工业出版社), 2016: 7.       Preparation and application of an emodin-bonded silica gel chromatographic
            [2]   Zhao W W,Zhang C Y,Yan Z G, et al. Preparation, characterization, in   column  for  high  performance  liquid  chromatography[J].  Chin  J
                 HPLC  for  stationaryphase  and  performance  evaluation  of  UiO-66   Chromatogr (色谱), 2014, 32(8): 798- 803.
                 analogues  as  the  separation  of  substituted  benzenes  and  polycyclic   [16]  Lu  Peizhang  (卢佩章),  Dai  Chaozheng  (戴朝政),  Zhang Xiangmin
                 aromatic hydrocarbons[J]. PLoS One, 2017, 12(6): e0178513. DOI:   (张祥民).  Theoretic  bases  of  chromatography:  Second  Edition[M].
                 10. 1371/journal. pone. 0178513.                  Beijing: Science Press(科学出版社), 1997: 273.
   132   133   134   135   136   137   138   139   140   141   142