Page 99 - 《精细化工》2021年第6期

第 6 期 靳玉慎，等: pH 敏感的 PLGA 包覆 Ag 2 S 团簇用于近红外Ⅱ区荧光引导的肝癌手术切除 ·1161·

做任何处理）相比，近红外Ⅱ区荧光引导的手术切 [6] ELVIN B, HAIFA S, MAURO F. Principles of nanoparticle design
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除可将肿瘤基本清除干净，只有个别荷瘤老鼠在手
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术后第 40 d 复发，且 60 d 荷瘤小鼠的生存率达到了 [7] MI P, KOKURYO D, CABRAL H, et al. A pH-activatable nanoparticle
90%，而传统手术组大部分荷瘤小鼠的肿瘤未被清 with signal-amplification capabilities for non-invasive imaging of
tumour malignancy[J]. Nature Nanotechnology, 2016, 11: 724-730.
除干净，荷瘤小鼠肿瘤增长迅速，荷瘤小鼠在 60 d [8] LUKIANOVA-HLEB E Y, KIM Y, BELATSARKOUSKI I, et al.
内的生存率只有 40%。此外，在实验过程中，对于 Intraoperative diagnostics and elimination of residual microtumours
近红外Ⅱ区荧光引导的手术切除组来说，荷瘤小鼠 with plasmonic nanobubbles[J]. Nature Nanotechnology, 2016, 11:
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的体重明显增长，而对照组荷瘤小鼠的体重明显下 [9] JIN Y S, YANG X, TIAN J. Targeted polypyrrole nanoparticles for
降，传统手术组荷瘤小鼠的体重呈先增长后下降趋 identification and treatment of hepatocellular carcinoma[J].
Nanoscale, 2018, 10: 9594-9601.
势，表明 SP94-PLGA@Ag 2 S 纳米粒子的注射以及手 [10] YANG Z G (杨志广), ZHANG L Y (张璐瑶), CHEN Y H (陈亚红),
术并未对荷瘤小鼠产生明显的不良影响，而肿瘤的 et al. Research progress of organic fluorescent small molecule probes
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[11] YIN P (尹培), MA L M C (马拉毛草), MA H C (马恒昌). Synthesis
3 结论 and cell imaging of triphenylamine-based fluorescent probe[J]. Fine
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本研究成功地构建了 SP94-PLGA@Ag 2 S 纳米 [12] DIP F, BONI L, BOUVET M, et al. Consensus conference statement on
the general use of near-infrared fluorescence imaging and indocyanine
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green guided surgery: Results of a modified delphi study[J]. Annals of
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解离导致近红外Ⅱ区荧光信号增加了 4 倍，而靶向 [13] ZHANG X, HE S Q, DING B B, et al. Cancer cell membrane-coated
rare earth doped nanoparticles for tumor surgery navigation in NIR-
多肽 SP94 的修饰使纳米粒子能够高效地富集到肿 Ⅱimaging window[J]. Chemical Engineering Journal, 2020, 385
瘤部位，随着时间的延长，SP94-PLGA@Ag 2 S 纳米 123959.
[14] GU Y P, CUI R, ZHANG Z L, et al. Ultrasmall near-infrared Ag 2Se
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区荧光信号，使其与周围的正常组织区分开来（48~ Journal of the American Chemical Society, 2012, 134(1): 79-82.
72 h），能够精准引导手术切除，大大延长荷瘤小鼠 [15] HAO X X, LI C Y, ZHANG Y J, et al. Programmable chemotherapy
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生存期，与传统手术组相比，荷瘤小鼠的 60 d 生存 fluorescence imaging in the second near-infrared window[J].
率从 40%提高到 90%。结果表明，SP94-PLGA@Ag 2 S Advanced Materials, 2018, 30(51): 1804437.
[16] CHEN G C, LIN S Y, HUANG D H, et al. Revealing the fate of
纳米粒子有望应用在临床上，可精准引导手术切除，
transplanted stem cells in vivo with a novel optical imaging
做到“不多切一分，也不少切一分”，减少术后肿瘤 strategy[J]. Small, 2018, 14(3): 1702679.
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