Page 75 - 《精细化工》2021年第8期
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第 8 期              孙君颖，等:  基于迷迭香精油温敏脂质体的响应型控释抗氧化复合膜制备                                   ·1569·


            显的温度响应控制释放特性。且经过与温敏脂质体                             参考文献：
            中精油释放行为的对比可知，将脂质体添加到薄膜                             [1]   GUILLEN M  D, GOICOECHEA  E. Formation of  oxygenated
            材料中并不会对其温控释放性能造成显著影响，其                                 α,β-unsaturated aldehydes and other toxic compounds in sunflower
                                                                   oil  oxidation at  room temperature in closed receptacles[J]. Food
            温度响应敏感程度并未降低。本文所制备的抗氧化                                 Chemistry, 2008, 111(1): 157-164.
            复合膜相较于非温度控制释放薄膜材料                   [29-31] 不仅可    [2]   LOPEZ-DE-DICASTILLO C, HERNANDEZ-MUNOZ P, GOMEZ-
            实现温控范围以下活性物质的缓释，还能够在达到                                 ESTACA J, et al. Advances in antioxidant active food packaging[J].
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            温控范围时快速释放活性物质，更有针对性地保护                             [3]   LLANA-RUIZ-CABELLO M, GUTIERREZ-PRAENA D, MAISANABA
            食品品质不受损害。                                              S,  et al. New  advances in active packaging incorporated with
            2.9   抗氧化复合膜 DPPH 自由基清除率分析                             essential oils  or their main components  for food preservation[J].
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                 通过测定 BOPP-多糖抗氧化复合膜的 DPPH 自                    [4]   LI C H (李春焕), WANG X Q (王晓琴), ZENG Q M (曾秋梅), et al.
            由基清除率来验证薄膜的抗氧化活性，结果见表 4。                               Research progress on oxidation process and mechanism, detection
                                                                   technology and influencing factors  of vegetable oil[J]. Food and
                表 4   抗氧化复合膜对 DPPH 自由基的清除活性                        Fermentation Industry (食品与发酵工业), 2016, 42(9): 277-284.
            Table 4    DPPH free radical scavenging activity of antioxidant   [5]   YING L, KANG E T, NEOH K G, et al. Drug permeation through
                    composite film                                 temperature-sensitive  membranes prepared from poly(vinylidene
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                         0.5 h    24 h     0.5 h    24 h       [6]   ZHOU J (周建),  ZHOU H (周虎), FAN H J (范浩军),  et al.
               对照组       0.918    0.918     0        0             Temperature-sensitive polyurethane  membrane for selective
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              抗氧化膜       0.585    0.524    36.27    42.90
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                 由表 4 可以看出，抗氧化复合膜在 0.5 h 的温育                       containing  lactoferrin and their action against carnobacterium
            期内其 DPPH 自由基清除率为 36.27%，略高于文献               [32]       viridans on bologna[J]. Journal of Food Science, 2010, 71(6): 208-214.
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            报道的添加了姜黄素的塔拉胶/聚乙烯醇抗氧化膜
                                                                   sensitive, indocyanine green-encapsulating micelles for noninvasive
            的 0.5 h 内 DPPH 自由基清除率 35.16%；抗氧化复                      near-infrared tumor  imaging[J]. Pharmaceutical Research, 2010, 27(9):
            合膜 DPPH 自由基清除率在 24 h 温育期内可达                            1900-1913.
            42.90%，略高于文献      [31] 报道的添加了茶多酚纳米粒子               [9]   XU M R (徐慕儒), SUN K (孙衎), WU H B (巫寒冰),  et al.
                                                                   Synthesis and self-assembling of thermosensitive double-hydrophic
            的纤维素/淀粉抗氧化膜的 DPPH 自由基清除率 41%。                          galactose polymer by raft polymerization[J]. Fine Chemicals (精细化
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            本文制备的抗氧化复合膜抗氧化性能优异。                                    Cancer Research, 2000, 60(5): 1197-1201.
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                 本文利用乙醚注入法制备迷迭香精油温敏脂质                          [13]  WANG  Y H (王一涵), XU  Y B (徐迎波), NING M (宁敏),  et al.
            体，并采用乳糖为冻干保护剂及具有较长预冻时间                                 Preparation technology and  formulation  optimization of  β-ionone
                                                                   temperature-sensitive liposomes[J]. Journal of Food and Biotechnology (食
            的冻干程序对温敏脂质体进行冷冻干燥保存。该工
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            艺条件下制备的温敏脂质体平均包封率为 65.6%，                          [14]  ERKAN N,  AYRANCI G,  AYRANCI E.  Antioxidant activities of
            分散性良好，具有显著温敏特性，主要温控范围为                                 rosemary (rosmarinus officinalis l.) extract, blackseed (nigella sativa
                                                                   l.) essential oil, carnosic acid, rosmarinic acid and sesamol[J]. Food
            39~42  ℃。以混合了迷迭香温敏脂质体的壳聚糖、                             Chemistry, 2008, 110(1): 76-82.
            普鲁兰多糖为基液，BOPP 为基膜采用流延法制得                           [15]  DEAMER D W. Preparation and properties of ether-injection
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            内释放率为 94.1%；在 39~42  ℃范围内释放速率快                     [16]  TESCHKE O, DE SOUZA E F. Liposome structure imaging by
            速升高，释放率急剧增大，具有显著的温控释放作                                 atomic force microscopy: Verification of improved liposome stability
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            到抗氧化复合膜，用于实现温控释放抗氧化剂这一                             [17]  WANG J ( 王健 ), LI M  X ( 李明轩 ). Research overview of
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            和实用性，为功能性食品包装材料的制备提供了一
                                                                   576-580.
            种思路，具有很强的应用潜力。                                                                   （下转第 1612 页）
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