Page 70 - 《精细化工》2021年第8期

第 38 卷第 8 期 精 细 化 工 Vol.38, No.8
202 1 年 8 月 FINE CHEMICALS Aug. 2021

功能材料
基于迷迭香精油温敏脂质体的响应型控释

抗氧化复合膜制备

1
3
孙君颖 ，卢莉璟 1,2 ，卢立新 1,2* ，林自东
（1. 江南大学 机械工程学院，江苏 无锡 214122；2. 江苏省食品先进制造装备技术重点实验室，江苏 无
锡 214122；3. 山东碧海包装材料有限公司，山东 临沂 276600）

摘要：以二棕榈酰磷脂酰胆碱（DPPC）和胆固醇为膜材，采用乙醚注入法制备迷迭香精油温敏脂质体，将温敏
脂质体添加到壳聚糖-普鲁兰多糖溶液中，以双向拉伸聚丙烯（BOPP）为基膜制备抗氧化复合膜。对迷迭香精
油温敏脂质体进行了包封率、粒径分布、多分散性指数（PDI）、相变温度和原子力显微镜的测定，测试了薄膜
中精油释放率，验证薄膜温度响应特性。结果表明，制备的温敏脂质体平均包封率为 65.6%，平均粒径为 164.8
nm，PDI 平均值为 0.163，相变温度为 38.5 和 41.8 ℃。抗氧化复合膜中精油在 42 ℃下 7 d 内释放率为 94.1%，
具有显著的温度响应控制释放作用。
关键词：温敏脂质体；温度敏感；普鲁兰多糖；壳聚糖；抗氧化；功能材料
中图分类号：TB383.2 文献标识码：A 文章编号：1003-5214 (2021) 08-1564-07

Preparation of responsive controlled-release antioxidant composite film

based on temperature-sensitive liposomes of rosemary essential oil

1,2
3
1
SUN Junying , LU Lijing , LU Lixin 1,2* , LIN Zidong
（1. School of Mechanical Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China; 2. Jiangsu Key Laboratory
of Advanced Food Manufacturing Equipment and Technology, Wuxi 214122, Jiangsu, China; 3. Shandong Bihai
Packaging Materials Co., Ltd., Linyi 276600, Shandong, China）

Abstract: Rosemary essential oil temperature-sensitive liposomes was prepared by ether injection method
using dipalmitoylphosphatidylcholine (DPPC) and cholesterol as film materials. Then, antioxidant
composite film was obtained by adding the temperature-sensitive liposomes into chitosan-pullulan solution
using biaxially oriented polypropylene (BOPP) as base film. The encapsulation efficiency, particle size
distribution, polydispersity index (PDI), phase transition temperature and atomic force microscopy of
rosemary essential oil temperature-sensitive liposomes were measured. The release rate of essential oil in
the antioxidant composite film was tested to verify the temperature response characteristics of the film. The
results showed that the average encapsulation efficiency of the prepared temperature-sensitive liposomes
was 65.6%, the average particle size was 164.8 nm, the average polydispersity index (PDI) was 0.163, and
the switching temperature was 38.5 and 41.8 ℃. The antioxidant composite film showed a release rate of
essential oil at 42 ℃ within 7 d was 94.1%, indicating that it had a significant temperature-responsive
release control effect.
Key words: temperature-sensitive liposomes; temperature-sensitivity; pullulan; chitosan; antoxidation;
functional materials

氧化酸败是食品变质的重要影响因素。近年来， 抗氧化活性包装膜因其能实现有效释放抗氧化剂，从

收稿日期：2021-02-20; 定用日期：2021-03-24; DOI: 10.13550/j.jxhg.20210179
基金项目：国家重点研发计划资助项目（2016YFD0400701）
作者简介：孙君颖（1995—），女，硕士生，E-mail：1060959004@qq.com。联系人：卢立新（1966—），男，教授，E-mail：
lulx@jiangnan.edu.cn。