Page 167 - 《精细化工》2021年第9期

第 38 卷第 9 期 精 细 化 工 Vol.38, No.9
202 1 年 9 月 FINE CHEMICALS Sept. 2021

医药与日化原料
高安全性富勒烯化妆品原料及其美白、抗炎、修复功效

1*
3
3
1
2
1
1
许 哲 ，李 慧 ，黄 勇 ，陆辉强 ，党 婧 ，孙泽川 ，王春儒
（1. 北京福纳康生物技术有限公司，北京 100102；2. 中国科学院化学研究所 分子纳米结构与纳米技术
重点实验室，北京 100086；3. 赣南师范大学 地理与环境工程学院，江西 赣州 341000）
摘要：采用物理分散法将富勒烯 C 60 分散于透明质酸钠（HA）或聚乙烯吡咯烷酮（PVP）中，制备了水溶性富
勒烯材料，富勒烯透明质酸钠（MHAF60）、富勒烯聚乙烯吡咯烷酮（PPF60），并对其护肤性能进行了测试。
UV-Vis 和 FTIR 结果显示，富勒烯 C 60 在 MHAF60 和 PPF60 中仍保持了其特征吸收。DLS 结果显示，MHAF60
和 PPF60 的粒径分别为 368.5 和 500.6 nm。GC 结果表明，两种材料均无有机溶剂残留。EPR 结果显示，MHAF60
淬灭自由基的能力要显著优于 PPF60、V C 和水溶性虾青素。以人表皮角质细胞（HEK-A）作为研究对象，测试
了在双氧水损伤条件下 MHAF60 对细胞的修复和保护作用，结果显示，MHAF60 的保护和修复效果是 V C 和水
溶性虾青素的 1.2 和 1.6 倍。斑马鱼模型实验结果显示，MHAF60 具有显著的抑制黑色素、抗炎修复功效，安全
性更高。
关键词：富勒烯；抗氧化；保护和修复；抑制黑色素；无刺激性；医药与日化原料
中图分类号：TQ658 文献标识码：A 文章编号：1003-5214 (2021) 09-1881-07

High safety fullerene cosmetic raw materials and their whitening,
anti-inflammatory and repairing effects

1*
1
1
3
3
XU Zhe , LI Hui , HUANG Yong , LU Huiqiang , DANG Jing ,
1
2
SUN Zechuan , WANG Chunru
（1. Beijing Funakang Biotechnology Co., Ltd., Beijing 100102, China; 2. CAS Key Laboratory of Molecular
Nanostructure and Nanotechnology, Institute of Chemistry Chinese Academy Sciences, Beijing 100086, China; 3. School
of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, Jiangxi, China）
Abstract: Two water-soluble fullerene materials, fullerene sodium hyaluronate (MHAF60) and fullerene
polyvinylpyrrolidone (PPF60) were prepared by physically dispersing fullerene C 60 in sodium hyaluronate
(HA) and polyvinylpyrrolidone (PVP), respectively, and their skin care properties were tested. UV-Vis and
FTIR results showed that fullerene C 60 still retained its characteristic absorption in MHAF60 and PPF60.
DLS results revealed that the particle sizes of MHAF60 and PPF60 were 368.5 and 500.6 nm, respectively.
GC results indicated that there was no residual organic solvent in the two materials. EPR measurements
indicated that the free radical quenching ability of MHAF60 was significantly better than that of PPF60, V C
and water-soluble astaxanthin. Human epidermal keratinocyte (HEK-A) cells was used to test the ability of
MHAF60 to repair oxidative damage in the presence of hydrogen peroxide, and protective and repairing
effects of MHAF60 were 1.2-fold and 1.6-fold those of V C and water-soluble astaxanthin. The results of
zebrafish experiments showed that fullerene C 60 could significantly inhibit melanin production, had
anti-inflammatory repairing inflammation and promote wound healing, with higher security.
Key words: fullerene; antioxidation; repairing and protection; inhibition of melanin; without stimulation;
drug and cosmetic materials

收稿日期：2021-02-05; 定用日期：2021-03-24; DOI: 10.13550/j.jxhg.20210141
基金项目：赤峰市 2020 年度“科技兴蒙”行动重点专项
作者简介：许 哲（1989—），男，中级工程师，E-mail: fullcanxz@163.com。联系人：李 慧（1983—），博士，E-mail: lihui1@
bjfullcan.com。