Page 118 - 《精细化工》2022年第8期

·1618· 精细化工 FINE CHEMICALS 第 39 卷

的增加，细胞存活率稍有下降，MIP、NIP 和市售 [8] DAMAR Μ, GERSNER R, JOHNSTONE J T, et al. Huperzine A: A
promising anticonvulsant, disease modifying, and memory enhancing
Hup A 片趋势一致，而且 MIP、NIP 的细胞存活率
treatment option in Alzheimer's disease[J]. Medical Hypotheses,
略高于市售 Hup A 片组，表明 MIP 和 NIP 具有良好 2017, 99: 57-62.
的生物相容性，适合作为缓释药物载体。 [9] GAO X (高璇)，CHEN Y Y (陈媛媛)，LIU Y Y (刘媛媛), et al.
Preparation and vitro release evaluation of huperzine A hydrogel
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3 结论 [10] SOLAK E K, ASMAN G, MΜHAMMET S M, et al. Controlled
release of huperzine A from biocompatible copolymer microspheres
基于分子印迹和沉淀聚合技术，以 Hup A 为模 [J]. Bulletin of Materials Science, 2019, 42(2): 1-7.
[11] CHEN Y F, CHENG G, HΜ R F, et al. A Nasal temperature and pH
板分子，MAA 为功能单体、EGDMA 为交联剂，AIBN
dual-responsive in situ gel delivery system based on microemulsion
为引发剂，通过热引发聚合成功制备了 MIP 微球， of huperzine A: Formulation, evaluation, and in vivo pharmacokinetic
微球尺寸分布均匀，单分散性良好。通过等温吸附 study[J]. AAPS Pharm Sci Tech, 2019, 20(7): 1-12.
[12] ZHANG M X, GΜ L L, KONG G H, et al. Comparative analysis of
实验和 Scatchard 方程对 MIP 上的结合位点进行分 atrazine molecularly imprinted polymers using acetonitrile and
析，结果表明，MIP 对 Hup A 具有特异性吸附性能, toluene as solvents[J]. Journal of Applied Polymer Science, 2019,
136(11): 1-8.
高浓度下平衡解离常数 K d=43.8596 mg/L，最大吸附
[13] WEI P J, SONG R M, CHEN C, et al. A pH-responsive molecularly
量 Q max=6.6644 mg/g；低浓度下平衡解离常数 K d = imprinted hydrogel for dexamethasone release[J]. Journal of Inorganic
287.3563 mg/L，最大吸附量 Q max =19.4080 mg/g。MIP and Organometallic Polymers and Materials, 2019, 29(3): 659-666.
[14] ZHANG S Z, ZHAO Y. Tuning surface-cross-linking of molecularly
在 1 h 后释放平缓，在 24 h 附近达到平衡，可以达 imprinted cross-linked micelles for molecular recognition in water[J].
到缓慢释放的效果，避免了传统方法存在的突释和 Journal of Molecular Recognition, 2019, 32(4): 1-19.
[15] CHEN H Q, ZHANG W, YANG N, et al. Chitosan-based surface
药物模板泄漏的问题。释放动力学符合 Peppas 模型，
molecularly imprinted polymer microspheres for sustained release of
释放指数 n=0.48，为非 Fickian 扩散机理。MIP 生物 sinomenine hydrochloride in aqueous media[J]. Applied Biochemistry
相容性良好，L929 小鼠成纤维细胞对 MIP 的细胞毒 and Biotechnology, 2019, 185(2): 370-384.
[16] LU P P (鲁佩佩), WANG B (王兵), ZHANG Y Y (张英英).
性数据显示，细胞存活率高于 93%。生物相容性良 Synthesis of aspirin imprinted polymer on silica gel surface and
好，安全低毒。因此，本研究制备的 MIP 适合作为 appreciation on drug sustained release[J]. Polymer Materials Science
& Engineering (高分子材料科学与工程), 2017, 33(1): 130-136.
药物缓控释载体材料。
[17] ZHANG W, SHE X H, WANG L P, et al. Preparation, characterization
and application of a molecularly imprinted polymer for selective
参考文献： recognition of sulpiride[J]. Materials, 2017, 10(5): 1-16.
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