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第 36 卷第 3 期 精 细 化 工 Vol.36, No.3
201 9 年 3 月 FINE CHEMICALS Mar. 2019

功能材料
载甲钴胺香蕉纤维素微晶/PLGA

介孔材料的制备及性能

*
庞锦英，黄春艳，谭登峰，莫羡忠，蓝春波 ，刘钰馨
（广西师范学院 化学与材料科学学院，广西 南宁 530001）

摘要：从香蕉树皮中提取香蕉纤维素微晶，将甲钴胺、香蕉纤维素微晶和乳酸-羟基乙酸共聚物(PLGA)制备成载
甲钴胺香蕉纤维素微晶/PLGA 介孔材料。运用 SEM、BET、TG-MS 和 FTIR 对产物进行了表征；采用紫外分光
光度计对载甲钴胺介孔材料进行了载药率、包封率、体外释放度测定。红外谱图分析表明，所制备的香蕉纤维
素微晶的主要成分为纤维素；BET 法测定结果表明，载甲钴胺香蕉纤维素微晶/PLGA 介孔材料的平均孔径
（4V/A）(V 为孔体积，A 为表面积)为 17.89 nm；TG-MS 结果表明，载甲钴胺香蕉纤维素微晶/PLGA 介孔材料分
解温度约为 300 ℃；体外释放实验表明，该材料对甲钴胺有较好的控释作用，药物释放遵循零级释放动力学方程。
关键词：香蕉纤维素微晶；甲钴胺；介孔材料；载体；缓释；功能材料
中图分类号：TB383.4 文献标识码：A 文章编号：1003-5214 (2019) 03-0368-06

Preparation and Properties of Banana Microcrystalline Cellulose/PLGA
Mesoporous Material Loading Mecobalamin

PANG Jin-ying, HUANG Chun-yan, TAN Deng-feng,
*
MO Xian-zhong, LAN Chun-bo , LIU Yu-xin
（College of Chemistry and Materials Science,Guangxi Teachers Education University, Nanning 530001,Guangxi, China）

Abstract:A mesoporous material loading mecobalamin was prepared using mecobalamin, banana
microcrystalline cellulose extracted from banana fiber and poly (lactic-co-glycolic acid) PLGA. The
products were characterized by SEM, specific surface area and pore size analysis (BET), thermogravimetric
analysis-mass spectrometry (TG-MS) and FTIR. The drug loading content,encapsulation efficiency, and in
vitro release rate of mesoporous material loading mecobalamin were studied by UV spectrophotometry.
FTIR analysis showed that the main component of the prepared banana microcrystalline cellulose was
cellulose. The BET results showed that the average pore diameter〔4V (pore volume)/A (surface area)〕of
banana microcrystalline cellulose/PLGA mesoporous material loading mecobalamin was 17.89 nm. TG-MS
results demonstrated that the decomposition temperature of the mesoporous material loading mecobalamin
was about 300 ℃. In addition, the material had a great controlled release for mecobalamin and the drug
release followed the zero-order release kinetics.
Key words: banana microcrystalline cellulose; mecobalamin; mesoporous material; carrier; controlled
release; functional materials
Foundation items: Open Foundation of Guangxi Key Laboratory of Processing for Non-ferrous Metals and
Featured Materials (GXYSOF1802); Open Foundation of Guangxi Key Laboratory of Natural Polymer
Chemistry and Physics (2018ZYB07); Guangxi College Students' Innovation and Entrepreneurship Training
Program (201810603140)

收稿日期：2018-07-31; 定用日期：2018-11-06; DOI: 10.13550/j.jxhg.20180571
基金项目：广西有色金属及特色材料加工重点实验室开放基金（GXYSOF1802）；广西天然高分子化学与物理重点实验室培育基地开
放基金（2018ZYB07）；广西区级大学生创新创业训练计划项目（201810603140）
作者简介：庞锦英（1980—），女，硕士，高级实验师。联系人：蓝春波（1985—），男，博士，讲师，E-mail：lanchunbo@126.com。