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第 4 期                     张孝焱,等:  谷胱甘肽-富勒烯光敏剂的合成及光动力学                                    ·587·


            中。细胞测试结果表明,内源性的 GSH 使 C 60 -OH-                        Small, 2012, 8(13): 2070-2077.
                                                               [8]   Liu Q, Xu L, Zhang X, et al. Enhanced photodynamic efficiency of
            GSH 具有优异的生物相容性,在 50 µmol/L 的高浓度                        an  aptamer-guided  fullerene  photosensitizer  toward  tumor  cells[J].
            下没有出现细胞毒性,同时在光照条件下 1  µmol/L                           Chemistry-An Asian Journal, 2013, 8(10): 2370-2376.
                                                               [9]   Constantin  C,  Neagu  M,  Ion  R  M,  et al.  Fullerene–porphyrin
            的 C 60 -OH-GSH 即可产生活性氧,从而诱导多种肿                         nanostructures  in  photodynamic  therapy[J].  Nanomedicine,  2010,
            瘤细胞凋亡,作为一种安全高效的光敏剂有望应用                                 5(2): 307-317.
                                                               [10]  Guan M, Li J, Jia Q, et al. A versatile and clearable nanocarbon ther-
            于临床光动力肿瘤治疗中。                                           anostic based on carbon dots and gadolinium metallofullerene nano-
                                                                   crystals[J]. Advanced Healthcare Materials, 2016, 5(17): 2283-2294.
            参考文献:                                              [11]  Xie Yaqing (谢雅清), Liang Xiaomei (梁晓美), Ye Weixia (叶伟霞)
                                                                   et al.Advances in pharmacological action and clinical application of
            [1]   Yano S, Hirohara S, Obata M, et al. Current states and future views
                 in  photodynamic  therapy[J].  Journal  of  Photochemistry  and   reduced  glutathione[J].  China  Pharmacceuticals  (中国药业),  2013,
                 Photobiology C: Photochemistry Reviews, 2011, 12(1): 46-67.   220(7): 124-127.
            [2]   Celli  J  P,  Spring  B  Q,  Rizvi  I,  et al.  Imaging  and  photodynamic   [12]  Yuan  Pingge  (袁平戈),  Zhang  Dazhi  (张大志).  Mechanism  and
                 therapy:  mechanisms,  monitoring,  and  optimization[J].  Chemical   clinical application of reduced glutathione[J]. Drug Evaluation (药品
                 Reviews, 2010, 110(5): 2795-2838.                 评价), 2006, 3(5): 385-390.
            [3]   Li Libo (李黎波), Li Wenmin (李文敏), Xiang Leihong (项蕾红), et   [13]  Wu  Qilin  (吴琪琳),  Cheng  Chaoge  (程朝歌),  Li  Min  (李敏),  et
                 al.  Photodynamic  therapy:  Clinical  research  and  application  in   al.Characterization techniques for fullerenes and their derivatives[J].
                 China[J]. Chinese Journal of Laser Medicine and Surgery(中国激光  Polymer Bulletin (高分子通报), 2016(10): 94-104.
                 医学杂志), 2012, 21(5): 278-307.                  [14]  Bolskar R D, Benedetto A F, Husebo L O, et al. First soluble M@C 60
            [4]   Liu  Hong  (刘宏),  Xue  Jinping  (薛金萍), Jiang  Zhou (江舟),  et   derivatives provide enhanced access to metallofullerenes and permit
                 al.Clinical  application  of  photosensitizer  in  tumor  photodynamic   in  vivo  evaluation  of  Gd@C 60  [C(COOH) 2] 10  as  a  MRI  contrast
                 therapy  and  its  research  overview[J].  Chinese  Journal  of  Applied   agent[J]. Journal of the American Chemical Society, 2003, 125(18):
                 Chemistry (应用化学), 2013, 30(12): 1386-1392.        5471-5478.
            [5]   Dolmans  D  E,  Fukumura  D,  Jain  R  K.  Photodynamic  therapy  for   [15]  Shu  C  Y,  Zhang  E  Y,  Xiang  J  F,  et al.  Aggregation  studies  of  the
                 cancer[J]. Nature Reviews Cancer, 2003, 3(5): 380.   water-soluble  gadofullerene  magnetic  resonance  imaging  contrast
            [6]   Chiang  L  Y,  Upasani  R  B,  Swirczewski  J  W.  Versatile  nitronium   agent:  [Gd@C 82O 6(OH) 16  (NHCH 2CH 2COOH) 8] x[J].  Journal  of
                 chemistry  for  C 60  fullerene  functionalization[J].  Journal  of  the   Physical Chemistry B, 2006, 110(31): 15597-15601.
                 American Chemical Society, 1992, 114(26): 10154-10157.   [16]  Sun T, Zhang Y S, Pang B, et al. Engineered nanoparticles for drug
            [7]   Liu  Q,  Guan  M,  Xu  L,  et al.  Structural  effect  and  mechanism  of   delivery  in  cancer  therapy[J].  Angewandte  Chemie  International
                 C 70-carboxyfullerenes as efficient sensitizers against cancer cells[J].     Edition, 2014, 53(46): 12320-12364.



            (上接第 558 页)                                            Journal, 2016, 22(35): 12295-12300.
                                                               [50]  Gillies J M, Prenant C, Chimon G N, et al. Microfluidic technology
            [40]  Richard D Chambers, Mark A Fox , Darren Holling, et al. Versatile   for  pet  radiochemistry[J].  Applied  Radiation  and  Isotopes,  2006,
                 gas/liquid  microreactors  for  industry[J].  Chemical  Engineering  and   64(3): 333-336.
                 Technology, 2005, 28(3): 344-352.             [51]  Chun  Joong-Hyun,  Lu  Shuiyu,  Victor  W  Pike.  Rapid  and  efficient
                                                                                                          18
                                                                                          18
            [41]  Richard  D  Chambers,  Mark  A  Fox,  Graham  Sandford.  Elemental   radiosyntheses  of  meta-substituted  [ F]  fluoroarenes  from  [ F]
                 fluorine  part  18.Selective  direct  fluorination  of  1,3-ketoesters  and   fluoride  ion  and  diaryliodonium  tosylates  within  a  microreactor[J].
                 1,3-diketones using gas/liquid microreactor technology[J]. The Royal   European Journal of Organic Chemistry, 2011, (23): 4439-4447.
                 Society of Chemistry, 2005, 5(10): 1132-1139.   [52]  Romain  Bejot,  Arkadij  M  Elizarov,  Ed  Ball,  et al.  Batch-mode
                                                                                                 18
            [42]  Richard D Chambers, Robert C H Spink. Microreactors for elemental   microfluidic  radiosynthesis  of  n-succinimidyl-4-[ F]fluorobenzoate
                 fluorine[J]. Chemical Communications (Cambridge), 1999, 10: 883-884.     for  protein  labelling[J].  Journal  of  Labelled  Compounds  and
            [43]  Richard D Chambers, Mark A Fox, Graham Sandford, et al. Elemental   Radiopharmaceuticals, 2011, 54(3): 117-122.
                 fluorine part 20. Direct fluorination of deactivated aromatic systems   [53]  Mahito Atobe, Hiroyuki Tateno, Yoshimasa Matsumura. Applications
                 using  microreactor  techniques[J].  Journal  of  Fluorine  Chemistry,   of  flow  microreactors  in  electrosynthetic  processes[J].  Chemical
                 2007, 128(1): 29-33.                              Reviews, 2018, 118(9): 4541-4572.
            [44]  Jähnisch K, Baerns M, Hessel V, et al. Direct fluorination of toluene   [54]  Svetlana  V  Selivanova,  Linjing  Mu,  Johanna  Ungersboeck,  et al.
                 using  elemental  fluorine  in  gas/liquid  microreactors[J].  Journal  of   Single-step  radiofluorination  of  peptides  using  continuous  flow
                 Fluorine Chemistry, 2000, 105(1): 117-128.        microreactor[J].  Organic  &  Biomolecular  Chemistry,  2012,  10(19):
            [45]  Nuria  De  Mas,  Axel  Günther,  Martin  A  Schmidt,  et al.   3871-3874.
                 Microfabricated  multiphase  reactors  for  the  selective  direct   [55]  Rehana Ismail, Jonathan Irribaren, Muhammad Rashed Javed, et al.
                 fluorination  of  aromatics[J].  Industrial  and  Engineering  Chemistry   Cationic  imidazolium  polymer  monoliths  for  efficient  solvent
                 Research, 2003, 42(4): 698-710.                   exchange, activation and fluorination on a continuous flow system[J].
            [46]  Aiichiro  Nagaki,  Yuki  Uesugi,  Heejin  Kim,  et al.  Synthesis  of   Royal Society of Chemistry, 2014, 4(48): 25348-25356.
                 functionalized  aryl  fluorides  using  organolithium  reagents  in  flow   [56]  Christopher  D  Reed,  Guillaume  G  Launay,  Michael  A  Carroll.
                 microreactors[J]. Chemistry-An Asian Journal, 2013, 8(4): 705-708.   Evaluation  of  tetraethylammonium  bicarbonate  as  a  phase-transfer
                                                                                    18
            [47]  Andreas  Schuster,  Khellil  Sefiane,  Jack  Ponton.  Multiphase  mass   agent  in  the  formation  of  [ F]fluoroarenes[J].  Journal  of  Fluorine
                 transport   in   mini/micro-channels   microreactor[J].   Chemical   Chemistry, 2012, 143: 231-237.
                 Engineering Research and Design, 2008, 86(5): 527-534.   [57]  Chun  Joong-Hyun,  Lu  Shuiyu,  Lee  Yong-Sok,  et al.  Fast  and
                                                                                                    18
            [48]  Andreas  Schuster,  Ramachandran  Lakshmanan,  Jack  Ponton,  et al.   high-yield  microreactor  syntheses  of  ortho-substituted  [ F]fluoroarenes
                                                                                18
                 Simulation and design of a non-adiabatic multiphase microreactor[J].   from  reactions  of  [ F]fluoride  ion  with  diaryliodonium  salts[J].
                 International Journal of Chemical Reactor Egineering, 2003, 1. DOI:  Journal of Organic Chemistry, 2010, 75(10): 3332-3338.
                 10.2202/1542-6580.1054.                       [58]  Volker  Hessel,  Panagiota  Angeli,  Asterios  Gavriilidis,  et al.
            [49]  Su Yuanhai, Koen P L Kuijpers, Niels König, et al. A mechanistic   Gas-liquid  and  gas-liquid-solid  microstructured  reactors:    Contacting
                 investigation  of  the  visible-light  photocatalytic  trifluoromethylation   principles and applications[J]. Industrial and Engineering Chemistry
                 of  heterocycles  using  CF 3I  in  flow[J].  Chemistry-A  European   Research, 2005, 44(25): 9750-9769.
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