Page 41 - 《精细化工》2020年第5期

第 5 期 唐文强，等: 智能响应型纳米药物载体的研究进展 ·891·

明显。另外，光敏、超声敏感等外源可控纳米药物 platesomes for pH-responsive drug delivery and enhanced antitumor
载体的应用也受到较大限制，比如：光信号很难穿 activity[J]. Advanced Materials, 2019, 31(32): 1900795.
[15] YU J, ZHAO F, GAO W L, et al. Magnetic reactive oxygen species
透到深部组织，而超声敏感载体应用时需要施加高 nanoreactor for switchable magnetic resonance imaging guided
强度聚焦超声，其对大肿瘤的治疗存在一定的限制， cancer therapy based on pH-sensitive Fe 5C 2@Fe 3O 4 nanoparticle[J].
且声能过高会超出人体承受范围。因此，开发刺激 ACS Nano, 2019, 13(9): 10002-10014.
[16] FOULADI F, STEFFEN K, MALLIK S. Enzyme-responsive
信号强度可调，且信号对人体友好的智能型纳米药物 liposomes for the delivery of anticancer drugs[J]. Bioconjugate
载体具有极其重要的意义和深远的影响。 Chemistry, 2017, 28(4): 857-868.
[17] VEIMAN K, KUNNAPUU K, LEHTO T, et al. PEG shielded MMP
参考文献： sensitive CPPs for efficient and tumor specific gene delivery in
vivo[J]. Journal of Controlled Release, 2015, 209: 238- 247.
[1] VANOSDOL J, EKTATE K, RAMASAMY S, et al. Sequential HIFU
[18] SONG S, LEE S, LEE Y, et al. Enzyme-responsive destabilization of
heating and nanobubble encapsulation provide efficient drug
penetration from stealth and temperature sensitive liposomes in colon stabilized plasmid-lipid nanoparticles as an efficient gene delivery[J].
European Journal of Pharmaceutical Sciences, 2016, 91: 20-30.
cancer[J]. Journal of Controlled Release, 2017, 247: 55-63.
[2] ZHOU Z X, LU Z R. Molecular imaging of the tumor [19] ZHANG R L, LI Y, ZHANG M, et al. Hypoxia-responsive drug-drug
conjugated nanoparticles for breast cancer synergistic therapy[J].
microenvironment[J]. Advanced Drug Delivery Reviews, 2017, 113:
RSC Advances, 2016, 6: 30268-30276.
24-48.
[3] ZHANG W J, WANG F H, WANG Y, et al. pH and near-infrared [20] QIAN C G, YU J C, CHEN Y L, et al. Light-activated
hypoxia-responsive nanocarriers for enhanced anticancer therapy[J].
light dual-stimuli responsive drug delivery using DNA-conjugated
gold nanorods for effective treatment of multidrug resistant cancer Advanced Materials, 2016, 28(27): 3313-3320.
[21] KULKARNI P, HALDAR M, YOU S, et al. Hypoxia-responsive
cells[J]. Journal of Controlled Release, 2016, 232(28): 9-19.
polymersomes for drug delivery to hypoxic pancreatic cancer
[4] YANG G B, SUN X Q, LIU J J, et al. Light-responsive, singlet-
oxygen-triggered on-demand drug release from photosensitizer- cells[J]. Biomacromolecules, 2016, 17(8): 2507-2513.
[22] TORCHILIN V. Multifunctional, stimuli-sensitive nanoparti-culate
doped mesoporous silica nanorods for cancer combination therapy[J].
Advanced Functional Materials, 2016, 26(26): 4722-4732. systems for drug delivery[J]. Nature Reviews Drug Discovery, 2014,
13: 813-827.
[5] ZHU C L, HUO D, CHEN Q S, et al. A eutectic mixture of natural
[23] ZHANG L H, QIN Y, ZHANG Z M, et al. Dual
fatty acids can serve as the gating material for near-infrared-triggered
drug release[J]. Advanced Materials, 2017, 29(40): 1703702- pH/reduction-responsive hybrid polymeric micelles for targeted
chemo-photothermal combination therapy[J]. Advanced Drug
1703728.
[6] LIANG X L, GAO J, JIANG L D, et al. Nanohybrid liposomal Delivery Reviews, 2018, 75(15): 371-385.
[24] ZHANG A T, JUNG K, LI A H, et al. Recent advances in
cerasomes with good physiological stability and rapid temperature
responsiveness for high intensity focused ultrasound triggered local stimuli-responsive polymer systems for remotely controlled drug
chemotherapy of cancer[J]. ACS Nano, 2015, 9(2): 1280-1293. release[J]. Progress in Polymer Science, 2019, 99: 101164.
[7] MA M, XU H X, CHEN H R, et al. A drug-perfluorocarbon [25] AMANDA M, OARA N, KAMILLA N, et al. Near-infrared remotely
nanoemulsion with an ultrathin silica coating for the synergistic triggered drug-release strategies for cancer treatment[J]. Proceedings
effect of chemotherapy and ablation by high-intensity focused of the National Academy of Sciences of the United States of
ultrasound[J]. Advanced Materials, 2014, 26(43): 7378-7385. America, 2017, 114(47): 12419-12424.
[8] GAWALI S, BARICK K, SHETAKE N, et al. pH-labile magnetic [26] TALEBIAN S, FOROUGHI J, WADE S, et al. Biopolymers for
nanocarriers for intracellular drug delivery to tumor cells[J]. ACS antitumor implantable drug delivery systems: recent advances and
Omega, 2019, 4(7): 11728-11736. future outlook[J]. Advanced Materials, 2018, 30(31): 1706665.
[9] ZIED F, ENAAM J A, AIGUL K, et al. Doxorubicin-loaded [27] KOBAYASHI H, CHOYKE P. Near-Infrared photoimm-unotherapy
thermoresponsive superparamagnetic nanocarriers for controlled drug of cancer[J]. Accounts of Chemical Research, 2019, 52(8):
delivery and magnetic hyperthermia applications[J]. ACS Applied 2332-2339.
Materials & Interfaces, 2019, 11(34): 30610-30620. [28] LI S H, LIU R, JIANG X X, et al. Near-infrared light-triggered
[10] SUGUMARAN P, LIU X L, HERNG T S, et al. GO-functionalized near-infrared light-triggered sulfur dioxide gas therapy of cancer[J].
large magnetic iron oxide nanoparticles with enhanced colloidal ACS Nano, 2019, 13(2): 2103-2113.
stability and hyperthermia performance[J]. ACS Applied Materials & [29] VANKAYALA R, HWANG K. Near-infrared-light-activatable
Interfaces, 2019, 11(25): 22703-22713. nanomaterial-mediated phototheranostic nanomedicines: An emerging
[11] HUANG Z, TIPPARAJU S, KIRPOTIN D, et al. Formulation oaradigm for cancer treatment[J]. Advanced Materials, 2018, 30(23):
optimization of an ephrin A2 targeted immunoliposome 1706320.
encapsulating reversibly modified taxane prodrugs[J]. Journal of [30] ZHOU L, CHEN Z W, DONG K, et al. DNA-mediated construction
Controlled Release, 2019, 310: 47-57.. of hollow upconversion nanoparticles for protein harvesting and
[12] ZHANG T, LIU H, LI Y T, et al. A pH-sensitive nanotherapeutic near-infrared light triggered release[J]. Advanced Materials, 2014,
system based on a marine sulfated polysaccharide for the treatment 26(18): 2424-2430.
of metastatic breast cancer through combining chemotherapy and [31] NIU N, HE F, MA P A, et al. Up-conversion nanoparticle assembled
COX-2 inhibition[J]. Acta Biomaterialia, 2019, 99: 412-425. mesoporous silica composites: Synthesis, plasmon-enhanced
[13] XIE D B (谢德彪), SONG H J (宋华杰), CAO H L (曹红亮), et al. luminescence, and near-infrared light triggered drug release[J]. ACS
Synthesis of branched cyclic copolymer for pH-responsive drug Applied Materials & Interfaces, 2014, 6(5): 3250- 3262.
delivery system[J]. Fine Chemicals (精细化工), 2017, 34(10): [32] ZHOU S Q, SHANG L, ZHAO Y X, et al. Pd single-atom catalysts
1114-1118, 1125. on nitrogen-doped graphene for the highly selective photothermal
[14] LIU G N, ZHAO X, ZHANG Y L, et al. Engineering biomimetic hydrogenation of acetylene to ethylene[J]. Advanced Materials, 2019,