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·1876· 精细化工 FINE CHEMICALS 第 37 卷
图 9 磺胺二甲嘧啶(a)、对羟基苯甲酸(b)、磺胺二甲嘧啶摩尔分数分别为:0.21(c)、0.58(d)、0.78(e)固相的
SEM 图
Fig. 9 SEM images of SFZ (a), HBA (b), samples with SFZ molar fractions of 0.21 (c), 0.58 (d) and 0.78 (e)
综上所述,磺胺二甲嘧啶-对羟基苯甲酸共晶的 Crystal Growth &Design, 2014, 14(9): 4475-4486.
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XRD 特征峰出现在 9.7°、13.9°、14.8°、16.4°、18.9°、
danazol cocrystal with controlled supersaturation plays an essential
22.4°、26.9°处,DSC 熔点在 220.51 ℃和 221.69 ℃ role in improving bioavailability[J]. Molecular Pharmaceutics, 2013,
附近,SEM 图中共晶的形貌为棒状。 10(8): 3112-3127.
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2010[J]. Crystal Growth &Design, 2012, 12(2): 1046-1054.
pH 为 3.15,流速为 1.25 mL/min。该法能使磺胺二
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1~140 mg/L 范围内线性关系良好,且分离度高,峰 [10] KARAGIANNI A, MALAMATARI M, KACHRIMANIS K.
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形良好。该法精密度和稳定性高,回收率良好。
for the formulation of APIs[J]. Pharmaceutics, 2018, 10(1): 18.
(2)采用此法测定了磺胺二甲嘧啶和对羟基苯 [11] SCHULTHEISS N C, BETHUNE S J. Pterostilbene cocrystals:
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体系分别在 298.15 K 和 303.15 K 时的溶解度数据, Journal of Chemical & Engineering Data, 2015, 60(4): 1166-1172.
并绘制了对应的三元相图。对在 298.15 K 时的部分 [13] LEE K S, KIM K J, ULRICH J. Formation of salicylic acid/4,
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固相进行 XRD、DSC、SEM 表征。结果表明,随着 Chemical Engineering & Technology, 2015, 38(6): 1073-1080.
温度的升高,磺胺二甲嘧啶-对羟基苯甲酸共晶三元 [14] YAMAZAKI M, KAKEYA N, MORISHITA T, et al. Biological
相图的平衡液相线下移,不饱和区域及共晶区域增 activity of drugs. Relation of structure to the bacteriostatic activity of
sulfonamides[J]. Chem Pharm Bull, 1970, 18(4): 702-707.
大,升温有利于共晶的制备,且得到的相图是对称 [15] GHOSH S, BAG P P, REDDY C M. Co-crystals of sulfamethazine
相图,有利于共晶体的制备。 with some carboxylic acids and amides: Co-former assisted
tautomerism in an active pharmaceutical ingredient and hydrogen
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