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·1876·                            精细化工   FINE CHEMICALS                                 第 37 卷
















            图 9    磺胺二甲嘧啶(a)、对羟基苯甲酸(b)、磺胺二甲嘧啶摩尔分数分别为:0.21(c)、0.58(d)、0.78(e)固相的
                 SEM 图
                   Fig. 9    SEM images of SFZ (a), HBA (b), samples with SFZ molar fractions of 0.21 (c), 0.58 (d) and 0.78 (e)

                 综上所述,磺胺二甲嘧啶-对羟基苯甲酸共晶的                             Crystal Growth &Design, 2014, 14(9): 4475-4486.
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                                                                   danazol cocrystal with controlled supersaturation plays an essential
            22.4°、26.9°处,DSC 熔点在 220.51  ℃和 221.69  ℃              role in improving bioavailability[J]. Molecular Pharmaceutics, 2013,
            附近,SEM 图中共晶的形貌为棒状。                                     10(8): 3112-3127.
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            啶和对羟基苯甲酸含量的条件为:乙腈-磷酸水溶液                                2010, 22(5): 829-836.
            (体积比为 18∶82)为流动相,其中磷酸水溶液的                          [8]   BRITTAIN  H  G.  Cocrystal  systems  of  pharmaceutical  interest:
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            pH 为 3.15,流速为 1.25  mL/min。该法能使磺胺二
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            甲嘧啶和对羟基苯甲酸在 9  min 内迅速分离,在                             2010[J]. Crystal Growth & Design, 2012, 12(11): 5823-5832.
            1~140 mg/L 范围内线性关系良好,且分离度高,峰                       [10]  KARAGIANNI  A,  MALAMATARI  M,  KACHRIMANIS  K.
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            形良好。该法精密度和稳定性高,回收率良好。
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                (2)采用此法测定了磺胺二甲嘧啶和对羟基苯                          [11]  SCHULTHEISS  N  C,  BETHUNE  S  J.  Pterostilbene  cocrystals:
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            体系分别在 298.15 K 和 303.15 K 时的溶解度数据,                     Journal of Chemical & Engineering Data, 2015, 60(4): 1166-1172.
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            固相进行 XRD、DSC、SEM 表征。结果表明,随着                            Chemical Engineering & Technology, 2015, 38(6): 1073-1080.
            温度的升高,磺胺二甲嘧啶-对羟基苯甲酸共晶三元                            [14]  YAMAZAKI  M,  KAKEYA  N,  MORISHITA  T, et al.  Biological
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            大,升温有利于共晶的制备,且得到的相图是对称                             [15]  GHOSH S, BAG P P, REDDY C M. Co-crystals of sulfamethazine
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