Page 155 - 《精细化工》2022年第11期

第 39 卷第 11 期 精 细 化 工 Vol.39, No.11
2022 年 11 月 FINE CHEMICALS Nov. 2022

医药与日化原料
NIR 光响应型 PNIPAM-co-AA/GO 复合

体系的制备及药物释放

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朱敬洋，周益名 ，付志威，黄 倩
〔浙江理工大学 纺织科学与工程学院（国际丝绸学院），浙江 杭州 310018〕

摘要：采用乳液聚合法将 N-异丙基丙烯酰胺（NIPAM）与丙烯酸（AA）聚合为 PNIPAM-co-AA 微凝胶，并进
一步与氧化石墨烯（GO）超声共混得到 PNIPAM-co-AA/GO 复合体系，将其应用于药物释放研究。采用 FTIR、
TEM、DLS、UV-Vis 对微凝胶及复合体系的结构和性能进行了表征与测试。结果表明，PNIPAM-co-AA 微凝胶
的粒径为 458.7 nm，最低临界相转变温度（LCST）为 40 ℃，具有温度敏感性和 pH 敏感性。GO 的存在将
PNIPAM-co-AA/GO 复合体系的温度响应控制转化成了近红外（NIR）响应。复合体系受到 NIR 光照射，可在
3 min 内将 NIR 光能转化为热能达到微凝胶的 LCST，多次循环后光热转化性能稳定。药物释放实验结果表明，
有 NIR、pH 7.4，25 ℃条件下，PNIPAM-co-AA/GO〔AA 含量为 5%（以 NIPAM、BIS 和 SDS 物质的量之和为
基准，下同），GO 含量为 5%（以 PNIPAM-co-AA 质量为基准，下同）〕对 5-氟尿嘧啶（5-FU）在 24 h 的累积
释放率为 77.24%。
关键词：PNIPAM 微凝胶；氧化石墨烯；温度敏感性；pH 敏感性；近红外光热转化；药物释放；医药原料
中图分类号：FQ460.1 文献标识码：A 文章编号：1003-5214 (2022)11-2305-07

Preparation and drug release of NIR photosensitive
PNIPAM-co-AA/GO composite system

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ZHU Jingyang, ZHOU Yiming , FU Zhiwei, HUANG Qian
[College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou
310018, Zhejiang, China]

Abstract: PNIPAM-co-AA/GO composite system was synthesized by ultrasonic blending of GO and
PNIPAM-co-AA microgels which were prepared via emulsion polymerization of N-isopropylacrylamide
(NIPAM) and acrylic acid (AA), and its in vitro drug release performances were investigated. Meanwhile,
the microstructure and properties of PNIPAM-co-AA microgels and PNIPAM-co-AA/GO composite system
were characterized by FTIR, TEM, DLS and UV-Vis. The results showed that the PNIPAM-co-AA
microgels exhibited a particle size of 458.7 nm, lower critical solution temperature (LCST) of 40 ℃ , as well
as temperature and pH sensitivity. The presence of GO transformed the temperature response control of
PNIPAM-co-AA composite system into near infra-red (NIR) response. When irradiated by NIR light, the
composite system, converting the NIR light energy into heat energy, could obtain the LCST of microgel
within just 3 min, and the photothermal conversion performance was stable after several cycles. The drug
release study revealed that under the conditions of NIR irradiation and pH 7.4,25℃ ,the cumulative release
rate of PNIPAM-co-AA/GO [5% AA(based on the total mole of NIPAM, BIS and SDS), 5% GO(based on
the mass of PNIPAM-co-AA)] to 5-fluorouracil (5-FU) within 24 h reached up to 77.24%.
Key words: PNIPAM-based microgels; graphene oxide; temperature sensitivity; pH sensitivity; NIR
photothermal conversion; drug release; drug materials

收稿日期：2022-03-14; 定用日期：2022-06-06; DOI: 10.13550/j.jxhg.20220222
基金项目：国家自然科学基金青年基金项目（21908202）；中国博士后科学基金项目（2020M671794）
作者简介：朱敬洋（1998—），男，硕士生。联系人：周益名（1985—），女，副教授，E-mail：303547664@qq.com。