Page 167 - 《精细化工》2023年第11期

第 11 期 宋添力，等: 竹节参多糖通过 PI3K/AKT/NF-κB 信号通路对急性肝损伤大鼠的影响 ·2479·

（P<0.05）；与模型组相比，用药组 p-PI3K 蛋白表 产研究), 2023, 45(4): 57-68.
[16] TANG L (唐浪), SONG T L (宋添力), WU G Y (吴广阳), et al.
达显著上升（P<0.05），p-AKT、IL-1β 蛋白表达显 Anti-oxidative protection of Panax japonicus polysaccharide on
著下降（分别为 P<0.01、P<0.05），表明 PSPJ 可有 CCl 4-induced acute liver injury in rats based on Nrf2-ARE signaling
pathway[J]. Chinese Traditional and Herbal Drugs (中草药), 2023,
效抑制 ALI PI3K/AKT/NF-κB 信号通路的激活。 54(15): 1-9.
[17] JEON Y D, LEE J H, LEE Y M, et al. Puerarin inhibits inflammation
综合结果表明，PSPJ 可减轻炎性细胞因子和凋 and oxidative stress in dextran sulfate sodium induced colitis mice
亡蛋白表达，从而对 ALI 大鼠产生保护作用，其作 model[J]. Biomedicine & Pharmacotherapy, 2020, 124: 109847.
[18] ZHANG J (张杰), LI C Y (李春艳), LI J P (李劲平), et al.
用可能与抑制 PI3K/AKT/NF-κB 通路活化有关：通 Comparative study on the determination of polysaccharide inrhizoma
过增强氧化应激水平，降低 p-AKT、IL-1β、NF-κB of Panax japonicus by anthrone sulfuric acid method phenol sulfuric
method[J]. Zhongnan Pharmacology ( 中南药学 ), 2012, 10(6):
等炎症指标，从而发挥其抗炎、抗氧化的作用。然 421-424.
而，本研究仍存在一定的不足，缺少体外实验（如 [19] TAO Y Y (陶艳艳), CHEN G F (陈高峰), LIU C H (刘成海).
Evaluation of animal models of acute liver injury and its application
细胞水平）的机制研究，后期将以此为基础，继续 in pharmacology of traditional Chinese medicine[J]. Shanghai
Journal of Traditional Chinese Medicine (上海中医药杂志), 2019,
深入系统的研究，为其临床上开发保肝药提供更多
53(11): 12-19.
的实验和理论依据。 [20] NAN C Y (南彩云), ZHONG G Y (钟国跃), ZHU J X (朱继孝),
et al. Protective effects of five chemical constituents from Dianthus
参考文献： caryophyllus flowers on mice with carbon tetrachloride liver
injury[J]. Chinese Pharmacological Bulletin (中国药理学通报),
[1] ZHENG Y F, CUI B P, SUN W R, et al. Potential crosstalk between 2019, 35(2): 255-260.
liver and extra-liver organs in mouse models of acute liver injury[J]. [21] YANG Z Q (杨忠奇). Dosage interpretation of proprietary Chinese
International Journal of Biological Sciences, 2020, 16(7): 1166-1179. medicines in the Chinese pharmacopoeia 2020[M]. Beijing: China
[2] TREFTS E, GANNON M, WASSERMAN D H. The liver[J]. Medical Science and Technology Press (中国医药科学技术出版社),
Current Biology, 2017, 27(21): 1147-1151. 2021.
[3] KHOURY T, RMEILEH A A, YOSHA L, et al. Drug induced liver [22] LIU X X (刘欣欣), ZUO C L (左翠玲), SUN L N (孙丽娜), et al.
injury: Review with a focus on genetic factors, tissue diagnosis, and Research progress of natural polysaccharides as nanocarriers for the
treatment options[J]. Journal of Clinical and Translational Hepatology, treatment of inflammatory bowel disease[J]. Modern Food Science
2015, 3(2): 99-108. and Technology (现代食品科技), 2023, 39: 10-17.
[4] ZHANG C, SHI X, SU Z P, et al. CD36 deficiency ameliorates [23] ZHANG Y, WU Z J, LIU J X, et al. Identification of the core active
drug-induced acute liver injury in mice[J]. Molecular Medicine, structure of a Dendrobium officinale polysaccharide and its
2021, 27(1): 57. protective effect against dextran sulfate sodium-induced colitis via
[5] FENG X, BAO J Y, SONG C X, et al. Functional role of miR-155 in alleviating gut microbiota dysbiosis[J]. Food Research International,
physiological and pathological processes of liver injury (review)[J]. 2020, 137: 109641.
Molecular Medicine Reports, 2021, 24(4): 714. [24] ZHENG H (郑宏), WANG L (王蕾)，ZOU H Y (邹海艳). Study on
[6] MORRIS S M, CHAUHAN A. The role of platelet mediated effects of total saponins of Panacis Japonici Rhizoma on
thromboinflammation in acute liver injury[J]. Front Immunol, 2022, lipopolysaccharide-induced inflammation in BV2 cells and its
13: 1037645. mechanism[J]. China Journal of Traditional Chinese Medicine
[7] ZHANG Y, XUE W L, ZHANG W Q, et al. Histone Information (中国中医药信息杂志), 2023, 30(08): 106-112.
methyltransferase G9a protects against acute liver injury through [25] SCHOLTEN D, TREBICKA J, LIEDTKE C, et al. The carbon
GSTP1[J]. Cell Death & Differentiation, 2020, 27(4): 1243-1258. tetrachloride model in mice[J]. Lab Anim, 2015, 49(S1): 4-11.
[8] YANG W C, TAO K X, ZHANG P, et al. Maresin 1 protects against [26] LIU Y (刘宇). Protective effect of α-hederin on CCl 4-induced acute
lipopolysaccharide/d-galactosamine-induced acute liver injury by liver injury and mechanism study[D]. Henan University of Science
inhibiting macrophage pyroptosis and inflammatory response[J]. and Technology (河南科技大学), 2022.
Biochem Pharmacol, 2022, 195: 114863. [27] HWA Y L, YOUNG Y, HAN J C. The effects of herbal extracts on
[9] WANG X B (王宪波), WANG X J (王晓静), LIU H M (刘慧敏), CCl 4-induced ROS accumulation and cell death in hepatocytes[J].
et al. Guidelines for the integrated traditional Chinese and Western Oriental Pharmacy and Experimental Medicine, 2018, 18(3): 257-264.
medicine diagnosis and treatment of acute-on-chronic liver failure[J]. [28] ZHANG X, ZHANG N F, KAN J, et al. Anti-inflammatory activity
Journal of Clinical Hepatobiliary Disease (临床肝胆病杂志), 2023, of alkali-soluble polysaccharides from Arctium lappa L. and its effect
39(7): 1547-1552. on gut microbiota of mice with inflammation[J]. International Journal
[10] VASQUES F, CAVAZZA A, BERNAL W. Acute liver failure[J]. of Biological Macromolecules, 2020, 154: 773-787.
Current Opinion in Critical Care, 2022, 28(2): 198-207. [29] WANG W Z (王文洲), GAO Q Q (高倩倩), CHEN Z (陈竹). Yunpi
[11] DONG V, NAN C R, KAR V C. Pathophysiology of acute liver xiefei huatan decoction alleviates airway inflammation and mucus
failure[J]. Nutrition in Clinical Practice, 2020, 35(1): 24-29. hypersecretion in young asthmatic rats via inhibiting PI3K/AKT/
[12] WU G, WIN S, THAN T A, et al. Gut microbiota and liver injury NF-κB signaling pathway[J]. Chinese Journal of Integrative Medicine
( Ⅰ )-acute liver injury[M]. Berlin: Advances in Experimental (中国中西医结合杂志), 2023, 43(9): 1108-1116.
Medicine and Biology, 2020. [30] LI D (李多), PENG Z (彭昭), ZHANG Z T (张泽天), et al. Reversal
[13] National Pharmacopoeia Commission. Three Parts of the of ulcerative colitis in rats by compound cypress liquid via PI3K/Akt/
Pharmacopoeia of the People's Republic of China[M]. Beijing: China NF-κB signaling pathway[J]. Chinese Journal of Gerontology (中国
Pharmaceutical Science and Technology Press (中国医药科技出版 老年学杂志), 2023, 43(9): 2241-2244.
社), 2020. [31] YAO D B, DONG M, DAI C L, et al. Inflammation and
[14] ZHOU J (周静), FU X Y (付先芸), CAI S J (蔡三金), et al. inflammatory cytokine contribute to the initiation and development
Research progress on chemical constituents and pharmacological of ulcerative colitis and its associated cancer[J]. Inflammatory Bowel
effects of Panax japonicus and predictive analysis on quality markers Diseases, 2019, 25(10): 1595-1602.
[J]. Chinese Traditional and Herbal Drugs (中草药), 2021, 52(9): [32] QIU L, FENG R B, WU Q S, et al. Total saponins from Panax
2819-2830. japonicus attenuate acute alcoholic liver oxidative stress and
[15] SONG T L (宋添力), SUN Y Z (孙永章), LI Q (李奇), et al. hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPAR
Mechanism of tujia medicine of fufang Panax japonicus tablets axis in vivo and in vitro[J]. Journal of Ethnopharmacology, 2023,
against liver injury: Based on network pharmacology and molecular 317: 116785.
docking[J]. Special Wild Economic Animal and Plant Research (特 （下转第 2534 页）