Page 100 - 《精细化工》2023年第4期
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g786g                             ㇫㏳ࡃጒ   FINE CHEMICALS                                 す 40 ࢤ

            ჋䭲ᵤ৮ᷭ≸͚⮱Ꮑ⩕ȡ఍ₑ喑ധλߌ㘪ࡃᵥ䚥ᣏ                             ቹڒ G-ఈ䨫Ҁ᝭ϔ⩌⮱㢔ٶԎत䭺ѻ喑ϻ㔹ᐧ⿸㢔
            䦵⮱ᬍ䚣䒲ߖԎतᩫ๔ឭᱜऄݝγᎬ∈ڠ∕                      [29-31] 喑  ٶᑧᏓ̻ఈ⣜㉍⊀Ꮣ͸䬡⮱ڠ㈨ȡ䄒᫦∂キӬᔘ䕌喑
            ͧᲱᐧ⽠ჇȠោ᎟ឝ⮱ោ⩌㉍₸⪆⩢ࡃ႓эᙌக᣽                             ᷭ≸䭽ͧ 0.029 ȝg/mL喑̻́ڣЃ፥㻮ោ⩌㉍⮱ϑࣶ
            ӈγᲮ๔⮱ӬݖȡHONG ぶ            [32] ጔໆ䃫䃎䃳ݘᣏ䦵喑           ࣺᏁजᔪ⪒̺䃎喑䃮ᬻڣᄦఈ⣜㉍ᷭ≸ڤᰶ䒰ສ⮱
            Ꭳౕ䒲ߖᣏ䦵⮱҉⩕̸჋⣝䲣ᴴᓗ⣜ݖ⩕喑हᬣ䃫                             ▢᩼ᕔহ䔶᠖ᕔȡౕധλᵥ䚥ᣏ䦵⮱ោ⩌㉍₸⪆㢔
            䃎ࣾ๦ᣏ䦵 H1 ̻ H2 ౕ䲣ᴴ㼓̸ࣾ䔈㵹䨫ᱯϑࣺ                         ٶэᙌᷭ≸͚喑ᵥ䚥ᣏ䦵̺ϲजВ҉ͧ䃳ݘٰУ喑
            Ꮑϔ⩌Ԏतᩫ๔喍ఫ 3B喑ڣ͚喑S1ȠS2ȠS3 ౴ͧ                        䔅जВ҉ͧԎत䒙ᢏহᩫ๔ٰУ喑᣽倅эᙌக⮱ܳ
            ࢂ䨫ᵥ䚥ᣏ䦵喑H1ȠH2 ͧ͑⻺ࣾ๦㐀Ჱ⮱ᵥ䚥ᣏ                           Ჽᕔ㘪ȡLUO ぶ      [38] Вᵥ䚥䔯䙺Ҁ҉ͧ䃳ݘᣏ䦵喑䃫
            䦵喎喑Ჱᐧγ̭⻺ᬍ䚣ᬍᴴ䃝⮱⩢ࡃ႓эᙌகȡ䄒                             䃎ο㶒 DNA ᣏ䦵҉ͧԎत䒙ᄩٰУ喑䃫䃎 Taqman
            ⩢ࡃ႓эᙌகౕᄦࢎ䗐䰶㉍⮱ᷭ≸͚㶕⣝ܧγ倅                              ᣏ䦵ͧԎतᣏ䦵喑Ⱋᴴ➖̻䃳ݘᣏ䦵⮱➦ᐯᕔ㐀व
            ▢᩼ᕔহ➦ᐯᕔ喑ᷭ≸䭽ͧ 16 fmol/Lȡ̷ౕ䔝⩢                        ᄩ㜡ο㶒 DNA ᣏ䦵̻Ԏतᣏ䦵ᒏ᜽ᱯϑࣹ䨫喑䔈㔹
            ࡃ႓эᙌக͚喑Y ಸ DNA ᣏ䦵হࣾ๦ᣏ䦵఍ڤᰶ                          ᑂܴࣾऐ䚣䒲ߖ⮱Ԏतᩫ๔ࣺᏁ喑჋⣝ᄦ⅕㟱㺬᳄
            㐀Ჱ▢≨ᕔহᲱ䆎⽠Ⴧᕔ喑ౕⰛᴴ➖䃳ݘȠԎत㼓                             ⮱倅➦ᐯᕔহ倅▢᩼ᕔᷭ≸ȡ
            ࣾহព෋᫦䲏ڤᰶ䛺㺮҉⩕ȡѳВ̷ᣏ䦵Ꮌ݄䃫䃎                                 э㐌㢔ٶധఏᴴ䃝䕇፥ႅౕ⽠ჇᕔጛȠ▢᩼Ꮣ
            䒰ฺᱯ喑ज㘪ϔ⩌㗹ᮜԎत倅Ƞմ䭠ᕔぶ䬛䷅ȡͧ                             ѻȠᷭ≸㗹ᮜฺᱯぶ㑧◦            [39] 喑ݖ⩕㏠ㆠᱽ᫆⠙➦⮱
            ₑ喑ⵁ⾣㔲Й㜡߈λхࡃ䃫䃎ᵥ䚥ᣏ䦵Ꮌ݄Ƞᐭࣾ                             㢔ٶᕔ䉕Ჱᐧฺवᱽ᫆ᵥ䚥ᣏ䦵जВᰶ᩵ٸ᰺э㐌
            ℁⢴ಸ⩢ࡃ႓эᙌக喑ᝃౕ⩢ࡃ႓эᙌக͚ᑂڒ็                             㢔ٶэᙌக⮱㑧◦喑ϻ㔹᣽倅эᙌகౕक़ฺᱯധ䉕
            䛺ᵥ䚣ᝃᬍ䚣䒲ߖԎतᩫ๔ゃ⪒ȠᲱᐧⷮᕔᵥ䚥ᣏ                             ᵤ৮͚⮱⽠Ⴧᕔহज䛺ฺᕔȡౕധλᵥ䚥ᣏ䦵⮱ោ
            䦵Ꭳ㐀वⷮ⤍ܳ⻨ゃ⪒喑В䭺ѻ㗹ᮜԎत᎟ឝহۼ                             ⩌㉍㢔ٶ⩌➖эᙌᷭ≸͚喑䛼ၽ◦Ƞ̷䒙ᢏ㏠ㆠ䷄
            ᄾմ䭠ᕔԎतȡ                                            ㆿぶᬍ⃿Ƞ⽠ჇȠ⩌➖Ⱕღᕔສ⮱㏠ㆠᱽ᫆㷘Ꭼ∈Ꮑ
                                                               ⩕ [40-41] ȡHE ぶ [42] Вᵥ䚥䔯䙺Ҁ҉ͧ䃳ݘᣏ䦵喑㐀व
            2   ധλᵥ䚥ᣏ䦵⮱ᷭ≸ោ⩌㉍₸⪆㢔ٶ⩌                              ⴠ෕☜䛼ၽ◦হ⅔ࡃⴠ෕☜⮱⠙➦ᕔ䉕喑Ჱᐧγ̭⻺
                ➖эᙌக                                           ڠ-ᐭ㢔ٶ∂ᷭ≸⸧㘧ι⩟୔ણ⮱㢔ٶ⩌➖эᙌக喍ఫ
                                                               4B喎ȡ䄒᫦∂ݖ⩕γⴠ෕☜䛼ၽ◦⾮ܧ⮱㢔ٶ➦ᕔ喑
                 㢔ٶ⩌➖эᙌக᭜ᠴᄳڤᰶ㢔ٶ᩵Ꮑ⮱ᴴ䃝➖                          हᬣВ⅔ࡃⴠ෕☜҉ͧ㢔ٶ⡊▚ݯ喑䭺ѻγ჋侹㗹ᮜ
            䕇䓴䲆⩢॥䭱҉⩕ȠڞФ҉⩕Вࣷϟহ㉍-⩌➖㉍ぶ                            Ԏत喑᣽倅γэᙌக⮱▢᩼ᏓȡLIU ぶ                [43] 䃫䃎ᵥ䚥
            ㈨㐌҉⩕֣㖁λܳၽ䃳ݘᅯ̷喑Ꭳ́ᵦᢛ᝭ࣾ⩌⮱                             ᣏ䦵Ꭳ̷̻䒙ᢏ㏠ㆠ䷄ㆿ⮱ࣾٶ➦ᕔⰥ㐀व喑Ჱᐧ
            㢔ٶᑧᏓअࡃᄦ䲣ᴴ䔈㵹ჇᕔჇ䛼ᷭ≸⮱⩌➖эᙌ                             γ̭⻺㢔ٶ⩌➖эᙌக⩕λ⸧㘧ι⩟⅔୔ણ⮱ᷭ≸喑
            க [33] ȡ㢔ٶэᙌகڤᰶ̺ऄ⍖ᏓȠ⅁Ҁぶ఍㉍ᒞ৺喑                       䄒эᙌகᄦ⸧㘧ι⩟⅔୔ણ⮱ᷭ≸䭽ѻ㜠 0.11 ng/mL喑
            Ҭ⩕ᄬপ䪬喑ᕔФ℁倅ぶх߬               [34-35] ȡᄳڤᰶ➦₷ߌ        Ꭳ᜽ߌᏁ⩕λ჋䭲冩ᵤ᱙⮱ᷭ≸͚ȡ
            㘪⮱ᵥ䚥ᣏ䦵㲺ڒ㢔ٶ⩌➖эᙌக⮱䃫䃎͚喑जᐭ
            ࣾោ⩌㉍₸⪆倅᩵ᷭ≸᫝᫦∂ȡ
                 ധλᵥ䚥ᣏ䦵Ჱᐧោ⩌㉍₸⪆㢔ٶэᙌக喑ज
            Вݖ⩕䲣ᴴ㼓ࣾ⮱ᣏ䦵㐀Ჱ䒙अᑂࣾ㢔ٶᑧᏓ⮱अ
            ࡃ喑ϻ㔹ᄦⰛᴴោ⩌㉍䔈㵹ᷭ≸ܳᲽȡDEHGHANI
            ぶ [36] ധλࣹ䨫 DNA ᣏ䦵ᄦϸႁι⅔ࡃ⵲㏠ㆠ䷄ㆿ
            ⮱ᄮ〜҉⩕喑Ჱᐧγ̭⻺ᬍᴴ䃝⮱㢔ٶэᙌக喑⩕
            λᷭ≸ࢎ䗐䰶㉍ȡⰛᴴ➖ࢎ䗐䰶㉍⮱ႅౕᄩ㜡ࣹ䨫
            DNA ᣏ䦵ܳ⻨ͧࢂ䨫喑Ҭᓄ඘ٲι⅔ࡃ⵲ᓛႁ⮱㢔
            ٶധఏ喍㒄ͦᬻ B喎ᓄݝ䛷ᩫ喑ϻ㔹Ҭ㢔ٶᑧᏓࣾ
            ⩌अࡃȡౕᰭ䔯᲎У̸喑䄒эᙌகᄦࢎ䗐䰶㉍⮱㏬ᕔ

            ᷭ≸㠰డͧ 24.75~137.73 nmol/L喑ᷭ≸䭽ͧ 7.5 nmol/Lȡ         ఫ 4   ധλ G-ఈ䨫Ҁᵥ䚥ᣏ䦵⮱ఈ⣜㉍㢔ٶ⩌➖эᙌக

            SUN ぶ  [37] В G-ఈ䨫Ҁ㐀Ჱᵥ䚥䔯䙺Ҁͧ䃳ݘᣏ䦵喑                        ⹧ᘼఫ喍A喎    [37] 喠ധλᵥ䚥ᣏ䦵֣㖁ⴠ෕☜㏠ㆠᱽ
            Вநਾᾆͧ㢔ٶᴀ᫆喑Ჱᐧγ̭⻺ᬍᴴ䃝⮱㢔ٶэ                                  ᫆⮱⸧㘧ι⩟୔ણ㢔ٶ⩌➖эᙌக⹧ᘼఫ喍B喎                  [42]
            ᙌக喍ఫ 4A喎喑჋⣝γᄦఈ⣜㉍⮱倅᩵ᷭ≸ȡ䃳ݘ                           Fig. 4    Schematic diagrams of fluorescence biosensors for
            ᣏ䦵̻䲣ᴴఈ⣜㉍͸䬡⮱➦ᐯᕔ䃳ݘ̻㐀वҬᓄᣏ                                   the detection of tetracycline based on G-quadruplex
                                                                            [37]
                                                                     probe (A)   and sulfamethazine based on nucleic acid
            䦵⮱ G-ఈ䨫Ҁ㐀Ჱࣾ⩌अࡃ喑ᄩ㜡㢔ٶᴀ᫆நਾᾆ                                 probe coupled with graphene nanomaterial (B) [42]
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