Page 151 - 《精细化工》2023年第6期

第 6 期 杨 欢，等: 硼碳氮纳米管的制备及靶向递送阿霉素的抗肿瘤性能 ·1301·

3 结论 33: 242001.
[8] YANG H (杨欢), LI W (李崴), XU M (许蒙), et al. Characterization
of hydroxylated boron nitride nanotubes and its effect on L02
通过改进的固相合成法制备了 BCNNTs，并利 cells[J]. Fine Chemicals (精细化工), 2021, 38(5): 941-946.
用 FA 修饰 BCNNTs 得到 FA-BCNNTs，用于负载化 [9] ALI-BOUCETTA H, AL-JAMAL K T, MCCARTHY D, et al.
Multiwalled carbon nanotube-doxorubicin supramolecular complexes
疗药物 DOX，构筑了 FA-BCNNTs-DOX 靶向载药体 for cancer therapeutics[J]. Chemical Communications, 2008, 8(4):
系。通过研究 FA-BCNNTs-DOX 体外抗肿瘤作用、 459-461.
[10] LIU Z, FAN A C, RAKHRA K, et al. Supramolecular stacking of
进入细胞的方式以及 pH 缓释行为，得出以下结论： doxorubicin on carbon nanotubes for in vivo cancer therapy[J].
（1）FA 经酯化反应实现了对 BCNNTs 的修饰， Angewandte Chemie International Edition, 2009, 48: 7668-7672.
[11] JI Z F, LIN G F, LU Q H, et al. Targeted therapy of SMMC-7721
FTIR、UV-Vis 分析证实了 FA 已成功修饰到 BCNNTs
liver cancer in vitro and in vivo with carbon nanotubes based drug
上，体外细胞毒性实验表明了 FA-BCNNTs 在质量 delivery system[J]. Journal of Colloid and Interface Science, 2012,
浓度高达 200 mg/L 时仍对 MDA-MB-231 细胞无毒， 365(1): 143-149.
[12] EMANET M, ŞEN Ö, ÇULHA M. Evaluation of boron nitride
这意味着 FA-BCNNTs 作为药物载体有非常好的应 nanotubes and hexagonal boron nitrides as nanocarriers for cancer
用前景； drugs[J]. Nanomedicine, 2017, 12(7): 797-810.
[13] MIYAMOTO Y, RUBIO A, COHEN M L, et al. Chiral tubules of
（2）DOX 通过非共价的 - 堆积和疏水作用负 hexagonal BC2N[J]. Physical Review, 1994, 50(7): 4976-4979.
载在 BCNNTs 和 FA-BCNNTs 上，其负载量分别为 [14] DOROZHKIN P S, GOLBERG D, BANDO Y, et al. Field emission
from individual B—C—N nanotube rope[J]. Applied Physics Letters,
87.11 和 67.33 mg/g，FA 的存在可以提高 BCNNTs 2002, 81(6): 1083-1085.
的载药量以及分散性； [15] MO L B, CHEN Y J, LUO L J. Solid-state reaction synthesis of
boron carbonitride nanotubes[J]. Applied Physics A, 2010, 100(1):
（3）体外细胞毒性实验表明，FA-BCNNTs-DOX、 129-134.
BCNNTs-DOX 和 DOX 均能使 MDA-MB-231 细胞活 [16] BI X F (闭晓帆), CHEN Y J (陈拥军), LI J (李娟), et al. Effect of
catalyst content on the formation of boron nitride nanotubes by
力明显降低，且都表现出了时间依赖性和剂量依赖
co-precipitation and annealing method[J]. Journal of Materials
性。其中，FA-BCNNTs-DOX 的体外抗肿瘤活性显 Science & Engineering (材料科学与工程学报), 2013, 31(4):
著高于 BCNNTs-DOX 和 DOX； 557-561.
[17] CAO L H (曹利华), CHEN Y J (陈拥军), LI J B (李建保), et al.
（4）FA-BCNNTs-DOX 以 FA 受体介导的方式 Ferrous chloride-catalyzed synthesis of boron carbonitride nanotube[J].
内化到癌细胞内部，通过靶向递送可以提高药物的 Journal of Synthetic Crystals (人工晶体学报), 2017, 46(3): 562-572.
[18] LI W, XIE X, WU T T, et al. Targeted delivery of Auristatin PE to
递送速率，减少药物剂量，使药物聚集在癌细胞处； Hep G2 cells using folate-conjugated boron nitride nanotubes[J].
（5）体外释放实验表明，FA-BCNNTs-DOX、 Materials Science & Engineering C-Materials for Biological
Applications, 2020, 109: 110509.
BCNNTs-DOX 具有 pH 响应性释放特点，避免了 [19] CIOFANI G, GENCHI G G, LIAKOS I, et al. A simple approach to
DOX 非选择性扩散对正常细胞的损伤，提高了药物 covalent functionalization of boron nitride nanotubes[J]. Journal of
Colloid and Interface Science, 2012, 374(1): 308-314.
的治疗效果和生物利用度。因此，FA-BCNNTs-DOX
[20] ZHOU T, ZHOU X M, XING D. Controlled release of doxorubicin
靶向给药系统的构建能有效提高抗肿瘤药物 DOX from graphene oxide based charge-reversal nanocarrier[J]. Biomaterials,
2014, 35(13): 4185-4194.
的治疗效率。
[21] HU H Q, YU J H, LI Y Y, et al. Engineering of a novel Pluronic
F127/graphene nanohybrid for pH responsive drug delivery[J].
参考文献： Journal of Biomedical Materials Research Part A, 2011, 100(1):
[1] LI J D (李进典), HONG X F (洪杏芳), ZHANG J (张健), et al. 141-148.
Advances in research on targeting drug delivery system of [22] FENG S N, ZHANG H J, YAN T, et al. Folate-conjugated boron
doxorubicin[J]. Progress in Pharmceutical Sciences (药学进展), nitride nanospheres for targeted delivery of anticancer drugs[J].
2014, 38(12): 910-915. International Journal of Nanomedicine, 2016, 11: 4573-4582.
[2] VEJPONGSA P, YEH E T H. Prevention of anthracycline-induced [23] HUANG H, YUAN Q, SHAH J S, et al. A new family of folate-
cardiotoxicity[J]. Journal of the American College of Cardiology, decorated and carbon nanotube-mediated drug delivery system:
2014, 64(9): 938-945. Synthesis and drug delivery response[J]. Advanced Drug Delivery
[3] LIU C (刘策), WANG Z X (王志祥), WU F W (武法文). Preparation Reviews, 2011, 63(14): 1332-1339.
of zeolitic imidazolate frameworks ZIF-8 and its application in the [24] FENG S N, ZHANG H J, XU S, et al. Folate-conjugated, mesoporous
drug response release[J]. Fine Chemicals (精细化工), 2019, 36(9): silica functionalized boron nitride nanospheres for targeted delivery
1767-1772. of doxorubicin[J]. Materials Science & Engineering C-Materials for
[4] PAN Y F (潘远凤). A multi-responsive nanogels for delivery of Biological Applications, 2019, 96: 552-560.
doxorubicin hydrochloride[J]. Fine Chemicals (精细化工), 2020, [25] YANG H, LI J X, GU S D, et al. Fabrication of hexagonal boron
37(12): 2554-2561. carbonitride nanoplates using for in vitro photodynamic therapy and
[5] YAGHOUBI A, RAMAZANI A. Anticancer DOX delivery system chemo therapy[J]. Colloids and Surfaces B: Biointerfaces, 2022, 212:
based on CNTs: Functionalization, targeting and novel technologies[J]. 112377.
Journal of Controlled Release, 2020, 327: 198-224. [26] FENG S N, ZHANG H J, ZHI C Y, et al. pH-Responsive charge-
[6] CHADAR R, AFZAL O, ALQAHTANI S M, et al. Carbon nanotubes reversal polymer-functionalized boron nitride nanospheres for
as an emerging nanocarrier for the delivery of doxorubicin for intracellular doxorubicin delivery[J]. International Journal of
improved chemotherapy[J]. Colloids and Surfaces B: Biointerfaces, Nanomedicine, 2018, 13: 641-652.
2021, 208: 112044. [27] WAN D (万冬), XI Y J (习钰晶), LI S F (李孙帆), et al. Progress on
[7] TURHAN E A, PAZARCEVIREN A E, ENIS Z, et al. Properties and nanocarriers in responsive to tumor microenvironment[J]. Chemical
applications of boron nitride nanotubes[J]. Nanotechnology, 2022, Industry and Engineering (化学工业与工程), 2021, 38(5): 80-87.