Page 179 - 《精细化工》2023年第9期

第 40 卷第 9 期 精 细 化 工 Vol.40, No.9
20 23 年 9 月 FINE CHEMICALS Sept. 2023

医药与日化原料
葡萄糖响应型丙烯基氧化石墨烯微凝胶

Pickering 乳液的制备及性能

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刘应林，秦艳琼，刘巍征，袁英慧，郝 红
（西北大学 化工学院，陕西 西安 710069）

摘要：以 3-丙烯酰胺基苯硼酸（AAPBA）和丙烯基氧化石墨烯（GOM）为原料，采用自由基聚合法制备了 GOM
微凝胶，再以该微凝胶为乳化剂构建了 Pickering 乳液。对 GOM 微凝胶进行 FTIR、SEM-EDS 表征及葡萄糖响
应性能测试。对 GOM 微凝胶 Pickering 乳液进行了荧光和粒径表征，并对其稳定性的影响因素进行了探究，以
胰岛素为模型药物，对载药乳液的体外控制释药性能进行了评价。结果表明，成功合成了 GOM 微凝胶。GOM
微凝胶中 GOM 添加量（以去离子水、AAPBA、丙烯酰胺、N,N'-亚甲基双丙烯酰胺、十二烷基硫酸钠、N,N-
二甲基丙烯酰胺的总质量为基准，下同）为 1.0%、GOM 微凝胶添加量为水相质量的 10.08%时，制备的水包
油（O/W）型 GOM 微凝胶 Pickering 乳液稳定性最好，平均粒径为 688.5 nm。GOM 微凝胶稳定的载药 Pickering
乳液在不同浓度葡萄糖溶液中约 5 h 达到释药平衡，当葡萄糖的浓度增至 40 mmol/L 时，胰岛素的 5 h 累积释放
率可达到 94.21%。
关键词：Pickering 乳液；丙烯基氧化石墨烯；葡糖糖响应性；GOM 微凝胶；医药原料
中图分类号：TQ460.4；O648.23 文献标识码：A 文章编号：1003-5214 (2023) 09-2027-07

Preparation and properties of glucose-responsive propylene-based
graphene oxide microgels Pickering emulsion

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LIU Yinglin, QIN Yanqiong, LIU Weizheng, YUAN Yinghui, HAO Hong
（School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China）

Abstract: Propylene-based graphene oxide (GOM) microgels were synthesized from free radical
polymerization of 3-acrylamidophenylboronic acid (AAPBA) and GOM, and then emulsified to form
Pickering emulsions. The GOM microgels obtained were characterized by FTIR and SEM-EDS, followed
by analysis on its glucose-responsive performance. Investigations were conducted to analyze the fluorescent
property and particle size distribution of the Pickering emulsion, the influencing factors on its stability as
well as the in vitro controlled drug release performance of insulin-loaded emulsion. Results from characterization
proved the successful synthesis of the GOM microgels. The oil in water (O/W)-type GOM microgel
Pickering emulsion obtained showed the best stability with an average particle size of 688.5 nm with 1.0%
of GOM (based on the total mass of deionized water, AAPBA, acrylamide, N,N'-methylene diacrylamide,
sodium dodecyl sulfate, N,N-dimethylacrylamide, the same below) added in GOM microgels and 10.08% of
GOM microgels mass in the aqueous phase. The GOM microgels-stabilized insulin-loaded Pickering
emulsion reached drug release equilibrium around 5 h in glucose solutions with different concentrations.
When the concentration of glucose was increased to 40 mmol/L, the cumulative release rate for 5 h of
insulin could reach 94.21%.
Key words: Pickering emulsions; propylene-based graphene oxide; glucose-responsivity; GOM microgels;
drug materials

[1]
与传统表面活性剂乳液相比，Pickering 乳液具 有在界面处稳定性好、用量少等优点 。目前，对

收稿日期：2022-11-16; 定用日期：2023-02-17; DOI: 10.13550/j.jxhg.20221035
作者简介：刘应林（1997—），男，硕士生，E-mail：15797895990@163.com。联系人：郝 红（1966—），女，教授，E-mail：haohong@nwu.edu.cn。