Page 179 - 《精细化工》2020年第8期
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第 8 期                  孙   跃,等:  苯并咪唑桥连的双-β-咔啉衍生物的合成与生物活性                               ·1677·


            抑制率分别为 100.0%和 92.4%,高于对照药多菌灵                          Fitoterapia, 2010, 81: 779-782.
            和嘧菌酯。对比这两个化合物的结构,发现其共同                             [5]   CHEN Q, CAO R H, CHEN H S, et al. Antitumor and neurotoxic
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            特点是在 β-咔啉环上 R -取代基均为苄基,这和课                             effects of novel harmine derivatives and structure-activity relationship
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                                 9
            题组前期相关研究中 R -苄基、3-氯苄基取代能够增
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                 以 1-取代-β-咔啉-3-羧酸乙酯为原料,经过烷基                    [9]   ASHOK P, CHANDER S, BALZARINI J, et al. Design, synthesis of
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