Page 183 - 《精细化工》2023年第8期

第 40 卷第 8 期 精 细 化 工 Vol.40, No.8
2 023 年 8 月 FINE CHEMICALS Aug. 2023

医药与日化原料
基于静电纺丝技术的农药传递体系的制备与性能

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吴焕岭 ，裔士钊 ，谢周良 ，冒海燕 ，汪茂勤 ，康正芳
（1. 盐城工学院 纺织服装学院，江苏 盐城 224051；2. 南京高正农用化工有限公司，江苏 南京
221000；3. 盐城市权航科技有限公司，江苏 盐城 224056）
摘要：为获得一种新型高载药率、易分散型农药制剂，基于药物传递理论，以阿维菌素（AVM）为农药模型、
乙基纤维素（EC）为主要农药载体、卡波姆（CB）为改性材料，利用静电纺丝技术构建了一种具有微纳结构的
农药传递体系。考察了复配比例、溶解参数及纺丝条件对农药传递体系性能的影响，采用 SEM、XRD 及 FTIR
对其进行了表征，对农药传递体系的载药率、利用率与光解率、释药率、释药动力学与药物释放机制及水分散
性进行了测试。结果表明，采用 N,N-二甲基乙酰胺与无水乙醇以体积比 3∶1 的混合液对载体 EC 与 CB 分别进
行溶解，EC（质量浓度 60 g/L）与 CB（质量浓度 30 g/L）溶液的体积均为 3.9 mL 时，农药传递体系的载药率
可达 35.7%，AVM 利用率可达 100%，耐光解性大幅提升。并且，该农药传递体系的水分散性非常优异，具有
长效释药性。
关键词：阿维菌素；农药制剂；静电纺丝；乙基纤维素；卡波姆；医药原料
中图分类号：TQ450.6；TQ340.64 文献标识码：A 文章编号：1003-5214 (2023) 08-1797-07

Preparation and properties of pesticide delivery system
based on electrospinning technology

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WU Huanling , YI Shizhao , XIE Zhouliang , MAO Haiyan ,
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WANG Maoqin , KANG Zhengfang
（1. College of Textile & Clothing, Yancheng Institute of Technology, Yancheng 224051, Jiangsu, China; 2. Nanjing
Gaozheng Agrochemical Co., Ltd., Nanjing 221000, Jiangsu, China; 3. Yancheng Quanhang Technology Co., Ltd.,
Yancheng 224056, Jiangsu, China）
Abstract: In order to obtain a new pesticide formulation with high drug-loading rate and good dispersion
property, a pesticide delivery system with special micro/nano composite structure was constructed with
avermectin (AVM) as pesticide model, ethyl cellulose (EC) as carrier, and carbomer (CB) as modification
material via electrospinning technology based on drug delivery theory. The effects of compound ratio,
dissolution parameters and electrospinning conditions on the performance of pesticide delivery system were
investigated. The pesticide delivery system obtained was then characterized by SEM, XRD and FTIR,
followed by analyses on its drug loading rate, utilization rate, photolysis rate, drug release rate, kinetics and
mechanism, and water dispersibility as well. The results showed that, when the mixture of
V(N,N-dimethylacetamide)∶V(anhydrous ethanol)=3∶1 used as solvent to dissolve EC and CB, and both
volume of EC (mass concentration of 60 g/L) and CB (mass concentration of 30 g/L) solutions of 3.9 mL,
the pesticide delivery system exhibited a drug-loading rate of AVM up to 35.7%, the AVM utilizing rate up
to 100%, and greatly improved photolysis resistance. Moreover, the pesticide delivery system displayed
excellent water dispersion and sustained drug release activities.
Key words: avermectin; pesticide formulation; electrospinning; ethyl cellulose; carbomer; drug materials

收稿日期：2022-10-25; 定用日期：2023-01-06; DOI: 10.13550/j.jxhg.20220977
基金项目：国家自然科学基金青年项目（52103067）；江苏省农业科技自主创新资金项目[CX(21)3086]；江苏省高等学校大学生创新
创业训练计划项目（202210305006Z）；盐城工学院校级科研资助项目（xjr2020042）；盐城工学院产学研合作项目（2022040414）
作者简介：吴焕岭（1982—），女，副教授，E-mail：wuhuanlingok@126.com。