Page 135 - 《精细化工》2023年第8期

第 40 卷第 8 期 精 细 化 工 Vol.40, No.8
20 23 年 8 月 FINE CHEMICALS Aug. 2023

功能材料
Cu(Ⅱ)配合物的制备、结构多样性及

超氧化物歧化酶活性

张文谦，牛亚杰，吴文荣，常笑玮，王东飞，张 帅

（信阳农林学院 制药工程学院，河南 信阳 464000）

摘要：为了构筑超氧化物歧化酶（SOD）模拟物，采用溶剂热法，以吡啶-3-羧酸-1-氧（HL1）和吡啶-4-羧酸-1-
氧（HL2）为有机配体，与一水合醋酸铜〔Cu(OAc) 2 •H 2 O〕金属盐反应合成了 3 种 Cu(Ⅱ)的配合物（CPs）：
[Cu 3 (HL1) 4 (OH) 2 (H 2 O) 2 ] n （CP1）、[Cu(HL2)(OH)] n （CP2）和[Cu(HL2)(CH 3 O)] n （CP3），其中 n 为正整数。通
过单晶 XRD、FTIR、元素分析、TGA、UV 光谱对其进行了结构和性能表征。CP1~3 在相似的溶剂热条件下合
成，却分别显示出一维、二维到三维的多维度构型，探讨了配体官能团的相对位置、配体的配位模式和溶剂体
系在配合物的结构多样性方面的可能机制。TGA 表明，CP1~3 可以分别稳定到 202、228、250 ℃，具有较好的热
稳定性，且 CP1~3 的维度越高，热稳定性越好。通过氯化硝基四氮唑蓝（NBT）光还原法测试得出，CP1~3 的
半数抑制浓度（IC 50 ）分别为 0.21、0.26、0.62 μmol/L，均具有一定的 SOD 活性，且 CP1~3 的维度越低，SOD
活性越好。其中，CP1 和 CP2 较低的 IC 50 表明其可作为有潜在应用前景的 SOD 模拟物。
关键词：铜(Ⅱ)配合物；吡啶-3-羧酸-1-氧；吡啶-4-羧酸-1-氧；SOD 活性；功能材料
中图分类号：O641 文献标识码：A 文章编号：1003-5214 (2023) 08-1749-09

Preparation, structural diversity and superoxide dismutase
activity of Cu(Ⅱ) coordination polymers

ZHANG Wenqian, NIU Yajie, WU Wenrong, CHANG Xiaowei,
WANG Dongfei, ZHANG Shuai
（School of Pharmaceutical Engineering, Xinyang Agricultural and Forestry University, Xinyang 464000, Henan, China）

Abstract: To construct superoxide dismutase (SOD) mimetics, three Cu(Ⅱ) coordination polymers (CPs),
[Cu 3(HL1) 4(OH) 2(H 2O) 2] n (CP1), [Cu(HL2)(OH)] n (CP2) and [Cu(HL2)(CH 3O)] n (CP3), in which n is a
positive integer, were synthesized from solvothermal reaction of pyridyl-3-carboxylic acid-1-oxide (HL1)
or pyridyl-4-carboxylic acid-1-oxide (HL2) with copper acetate monohydrate [Cu(OAc) 2•H 2O]. The CPs
obtained were then characterized by single crystal XRD, FTIR, elemental analysis, TGA and UV
spectroscopy for structure and property analyses. The results showed that CP1~3, though synthesized under
similar solvothermal conditions, exhibited a multi-dimensional configurations from one-dimension,
two-dimension to three-dimension, respectively. The possible mechanisms of the relative position of
functional groups in ligand, the coordination mode of ligand and the solvent system on the structural
diversity of CPs were also explored. TGA result revealed that CP1~3 could be stabilized up to 202, 228,
and 250 ℃, respectively, displaying good thermal stability, and the thermal stability improved as the dimension
increased. Nitrotetrazolium blue chloride (NBT) photoreduction test indicated that the median inhibition
concentration (IC 50) values of CP1~3 were 0.21, 0.26 and 0.62 μmol/L, respectively, showing certain SOD
activity which was enhanced as the dimension decreased. The lower IC 50 of CP1 and CP2 suggested that
they could be used as potential SOD mimetics.

收稿日期：2022-07-10; 定用日期：2022-09-30; DOI: 10.13550/j.jxhg.20220641
基金项目：河南省科技攻关项目（212102310343）；信阳农林学院高水平科研孵化器建设基金资助项目（FCL202008）
作者简介：张文谦（1992—），女，博士，E-mail：zwenqian@yeah.net。